213766-21-3 Usage
Uses
Used in Pharmaceutical Industry:
(2S)-2-[[[5-(TRIMETHYLSTANNYL)-3-PYRIDINYL]OXY]METHYL]-1-AZETIDINECARBOXYLIC ACID, T-BUTYL ESTER is used as a precursor for the synthesis of highly potent and selective ligands for AChR α4β2, such as 5-Iodo-A-85380. The compound serves as a crucial intermediate in the development of new drugs targeting the nicotinic acetylcholine receptor, which plays a significant role in various neurological disorders and cognitive functions.
Used in Radioiodination:
(2S)-2-[[[5-(TRIMETHYLSTANNYL)-3-PYRIDINYL]OXY]METHYL]-1-AZETIDINECARBOXYLIC ACID, T-BUTYL ESTER is also utilized in the field of radiochemistry as a suitable precursor for radioiodination. This process involves the introduction of radioactive iodine isotopes into the molecule, which can be used for various purposes, including the development of radiotracers for diagnostic imaging and targeted radiotherapy in oncology.
Used in Chemical Research:
The compound's unique structure and properties make it an interesting subject for chemical research. It can be employed in the study of various reaction mechanisms, synthetic strategies, and the exploration of new chemical transformations. Additionally, its potential applications in material science, such as the development of novel catalysts or the synthesis of advanced materials, can be investigated.
Biological Activity
Precursor to the highly potent and selective ligand for the α 4 β 2 nicotinic receptor, 5-Iodo-A-85380 (3-[(2S)-2-Azetidinylmethoxy]-5-iodopyridinedihydrochloride ). Suitable for radioiodination.
Check Digit Verification of cas no
The CAS Registry Mumber 213766-21-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,3,7,6 and 6 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 213766-21:
(8*2)+(7*1)+(6*3)+(5*7)+(4*6)+(3*6)+(2*2)+(1*1)=123
123 % 10 = 3
So 213766-21-3 is a valid CAS Registry Number.
213766-21-3Relevant academic research and scientific papers
NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND THE USES THEREOF
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Paragraph 1250; 1251; 1252, (2013/07/25)
The invention relates to pyridinyl nicotinic acetylcholine receptor ligands, compositions comprising an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand and methods to treat or prevent a condition, such as depression and nicotine dependence, comprising administering to an animal in need thereof an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand.
NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND THE USES THEREOF
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Page/Page column 227-228, (2010/04/30)
The invention relates to pyridinyl nicotinic acetylcholine receptor ligands, compositions comprising an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand and methods to treat or prevent a condition, such as depression and nicotine dependence, comprising administering to an animal in need thereof an effective amount of a pyridinyl nicotinic acetylcholine receptor ligand.
