213770-00-4Relevant academic research and scientific papers
1,3-Cycloaddition reactions of 2-oxo-2H-[1]benzopyran-4-carbonitrile N- oxide. Synthesis of several new 4-substituted coumarins
Nicolaides,Fylaktakidou,Litinas,Papageorgiou,Hadjipavlou-Litina
, p. 619 - 625 (2007/10/03)
1,3-Cycloaddition reactions of new 2-oxo-2H-[1]benzopyran-4-carbonitrile N-oxide 2 with dipolarophiles, o-aminophenols and o-phenylenediamine resulted in 4-heterocyclic substituted coumarin derivatives. These derivatives are screened for antiinflammatory activity in vitro through their antiproteolytic activity, the interaction with 1,1-diphenyl-2-picrylhydrazyl and the ability to affect superoxide anion and to inhibit β-glucuronidase and soybean lipoxygenase.
