213821-76-2

Upstream product

• 175777-31-8 (αR,4S)-N-[2-hydroxy-1-phenylethyl]-4-methyl-1,4-dihydro-2H-isoquinolin-3-one 
• 213821-84-2 (αR,4S)-[N-(2-hydroxy-1-phenylethyl)-4-methyl-3-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl]acetic acid ter-butyl ester 

Relevant academic research and scientific papers

4,4'-disubstituted 1,2,3,4-tetrahydroisoquinolines from alkylation of a chiral non racemic lactam. An approach to the crinine-type alkaloids

Enantiomerically pure 4,4-disubstituted tetrahydroisoquinolin-3-ones can be easily prepared by bis-alkylation of 1,2,3,4-tetrahyroisoquinolin-3-one 1 derived from (R)-(-)phenylglycinol. The observed diastereoselectivity was explained by a rigid chelated i