213831-72-2

Upstream product

• 2207-58-1 2,5-dihydroxy-6-methylbenzoquinone 
• 108-24-7 acetic anhydride 

Downstream Products

• 213831-88-0 2-acetoxy-5-methoxy-3-methyl-[1,4]benzoquinone 
• 213831-87-9 acetic acid 4-methoxy-5-methyl-3,6-dioxo-cyclohexa-1,4-dienyl ester 
• 1760-82-3 2,5-dimethoxy-3-methyl-[1,4]benzoquinone 
• 90111-36-7 2-hydroxy-5-methoxy-3-methylcyclohexa-2,5-diene-1,4-dione 
• 90111-37-8 5-hydroxy-2-methoxy-3-methyl-[1,4]benzoquinone 

Relevant academic research and scientific papers

Preparation and structure-activity relationships of novel asterriquinone derivatives

Asterriquinone (ARQ, la) is an antitumor metabolite of Aspergillus terreus IFO 6123. To gain insight into the structure-activity relationships of ARQ, a series of chemically modified derivatives (1 - 6), the ARQ analogues (b - e) and the 2,5-dihydroxy-p-benzoquinone analogues (f - h), were prepared, and cytotoxic activity against mouse leukemia P388 cells investigated. Results indicated that: 1) at least one hydroxy group or acetoxy group in the p-benzoquinone moiety is important to exhibit cytotoxicity; 2) in the p-benzoquinone moiety, a single methoxy group and/or one acetoxy group substitution showed more potent cytotoxicity than when two hydroxy groups are substituted (1); 3) the indole ring is important for the cytotoxicity of ARQ analogues; 4) the 1,1-dimethyl-2-propenyl group in the indole ring is not important for the cytotoxic activity of ARQ.