213883-33-1Relevant academic research and scientific papers
Reactions of α-thiocarboxamidocinna-monitrile derivatives with diethyl malonate: Synthesis of pyrazolo-[3,4-b]-α-pyridinone, thieno[2,3-b]-α-pyridinone,pyrido[2,3: 4′,5′]thieno[2,3-c]pyridazine and pyrido[2,3:4′,5′]-thieno[2,3-d]pyrimidinonethione derivatives
Attaby, Fawzy A.,Eldin, Sanaa M.,Abou-Abdou, Mohamed B.
, p. 121 - 133 (2007/10/03)
3-Cyano-4-aryl-5-ethoxycarbonyl-6-pyridinone-2-thione derivatives 3a-c reacted with several halogen-containing compounds to give the corresponding 2-S-methylpyridinones 4a-c, 2-S-acetonyl pyridinones 7a-c, 2-S-benzoyl methyl pyridinones 12a-c, 2-S-acetamidopyridinones 15a-c and 2-S-ethoxycarbonyl methylpyridinones 20a-c. The ethanolic solution of KOH used as a cyclization agent to give the corresponding thieno[2,3-b]pyridines 8a-c, 13a-c, 16a-c and 21a-c. Hydrazine hydrate, nitrous acid, carbon disulphide, acetic anhydride, formic acid, acetic acid and acetyl acetone gave further cyclization to construct an additional ring.
