213896-64-1 Usage
Uses
Used in Pharmaceutical Research:
[1,2,4]Triazolo[1,5-c]pyrimidin-5-amine, 7-chloro-2-(2-furanyl)is used as a building block for the synthesis of biologically active compounds in pharmaceutical research. Its unique structure and functional groups make it a valuable component in the development of new drugs with potential therapeutic applications.
Used in Drug Development:
In the pharmaceutical industry, [1,2,4]Triazolo[1,5-c]pyrimidin-5-amine, 7-chloro-2-(2-furanyl)is used as a starting material for the development of new drugs. Its potential applications include the treatment of various diseases, as its chemical structure can be modified and optimized to target specific biological pathways and receptors.
Used in Medicinal Chemistry:
[1,2,4]Triazolo[1,5-c]pyrimidin-5-amine, 7-chloro-2-(2-furanyl)is employed as a key intermediate in medicinal chemistry for the design and synthesis of novel therapeutic agents. Its heterocyclic structure and functional groups allow for a wide range of chemical modifications, enabling the creation of diverse drug candidates with improved pharmacological properties.
Used in Chemical Synthesis:
In the field of chemical synthesis, [1,2,4]Triazolo[1,5-c]pyrimidin-5-amine, 7-chloro-2-(2-furanyl)is used as a versatile intermediate for the preparation of various complex organic molecules. Its unique structure and reactivity make it an attractive candidate for the development of new synthetic routes and methodologies.
Check Digit Verification of cas no
The CAS Registry Mumber 213896-64-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,3,8,9 and 6 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 213896-64:
(8*2)+(7*1)+(6*3)+(5*8)+(4*9)+(3*6)+(2*6)+(1*4)=151
151 % 10 = 1
So 213896-64-1 is a valid CAS Registry Number.
213896-64-1Relevant academic research and scientific papers
Potent and selective adenosine A2A receptor antagonists: 1,2,4-Triazolo[1,5-c]pyrimidines
Neustadt, Bernard R.,Liu, Hong,Hao, Jinsong,Greenlee, William J.,Stamford, Andrew W.,Foster, Carolyn,Arik, Leyla,Lachowicz, Jean,Zhang, Hongtao,Bertorelli, Rosalia,Fredduzzi, Silva,Varty, Geoffrey,Cohen-Williams, Mary,Ng, Kwokei
scheme or table, p. 967 - 971 (2009/09/06)
Antagonism of the adenosine A2a receptor offers great promise in the treatment of Parkinson's disease. In the course of exploring pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine A2A antagonists, which led to clinical candidate SCH 420814, we prepared 1,2,4-triazolo[1,5-c]pyrimidines with potent and selective (vs A1) A2a antagonist activity, including oral activity in the rat haloperidol-induced catalepsy model. Structure-activity relationships and plasma levels are described for this series.
2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs: Highly potent, orally active, adenosine A2A antagonists. Part 1
Matasi, Julius J.,Caldwell, John P.,Zhang, Hongtao,Fawzi, Ahmad,Cohen-Williams, Mary E.,Varty, Geoffrey B.,Tulshian, Deen B.
, p. 3670 - 3674 (2007/10/03)
The structure-activity relationship of this novel class of compounds based on 2-(2-furanyl)-7-phenyl[1,2,4]-triazolo[1,5-c]pyrimidin-5-amine, 1, and its analogs was evaluated for their in vitro and in vivo adenosine A2A receptor antagonism. Several compounds displayed oral activity at 3 mg/kg in a rat catalepsy model. Specifically, compound 8g displayed an excellent in vitro profile, as well as a highly promising in vivo profile.
