213903-64-1Relevant articles and documents
3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol: The importance of functional groups for antiparkinsonian activity
Ardashov, Oleg V.,Pavlova, Alla V.,Korchagina, Dina V.,Volcho, Konstantin P.,Tolstikova, Tat'yana G.,Salakhutdinov, Nariman F.
, p. 731 - 739 (2013/09/23)
Compounds with different sets of three of the four functional groups of (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol 1 possessing high antiparkinsonian activity were synthesized. The synthesized compounds were tested for the antiparkinsonian activity in vivo on a mouse model with MPTP neurotoxin. A pronounced antiparkinsonian effect of 1 can only be achieved if it contains all the four functional groups (two hydroxy groups and two double bonds). The 2-hydroxy group or the 3,4-double bond is not required for stimulating the exploratory activity of the animals.
Hydrogenation and conformational analysis of (1R,2R,6S)-3-methyl-6-(1- methylethenyl)cyclohex-3-ene-1,2-diol
Ardashov,Genaev,Il'ina,Korchagina,Volcho,Salakhutdinov
experimental part, p. 1786 - 1789 (2011/04/17)
Hydrogenation of (1R,2R,6S)-3-methyl-6-(1-methylethenyl)cyclohex-3-ene-1,2- diol was studied. Nickel chloride-sodium tetrahydridoborate system turned out to selectively reduce the double bond in the isopropenyl group. The results of conformational analysis of (1R,2R,6S)-3-methyl-6-(1-methylethenyl)cyclohex-3- ene-1,2-diol and its partly and completely hydrogenated derivatives were in a good agreement with the NMR data. Pleiades Publishing, Ltd., 2010.
