213923-83-2

Basic information

• Product Name: 2-(2-bromo-4-isopropylanilino)-4-(5-phenyl-1,2,3,6-tetrahydropyridino)-6-methylpyrimidine
• Synonyms: 2-(2-bromo-4-isopropylanilino)-4-(5-phenyl-1,2,3,6-tetrahydropyridino)-6-methylpyrimidine
• CAS NO: 213923-83-2
• Molecular Weight: 463.42
• Mol File: 213923-83-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-bromo-4-isopropylanilino)-4-(5-phenyl-1,2,3,6-tetrahydropyridino)-6-methylpyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-bromo-4-isopropylanilino)-4-(5-phenyl-1,2,3,6-tetrahydropyridino)-6-methylpyrimidine(213923-83-2)
• EPA Substance Registry System: 2-(2-bromo-4-isopropylanilino)-4-(5-phenyl-1,2,3,6-tetrahydropyridino)-6-methylpyrimidine(213923-83-2)

Safety Data

• Hazardous Substances Data: 213923-83-2(Hazardous Substances Data)

Upstream product

• 5424-21-5 2,4-dichloro-6-methylpyrimidine 
• 108-86-1 bromobenzene 
• 98977-36-7 3-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 1056971-31-3 tert-butyl 5-phenyl-3,6-dihydro-2H-pyridine-1-carboxylate 
• 213923-81-0 N-tert-butoxycarbonyl-3-hydroxy-3-phenylpiperidine 

Relevant articles and documents

Synthesis and structure-affinity relationships of 4-(5-Aryl-1,2,3,6-tetrahydropyridino)pyrimidine derivatives as corticotropin-releasing factor1 receptor antagonists

Recently, various non-peptide corticotropin-releasing factor1 (CRF1) receptor antagonists have been reported. Structure-affinity relationships (SARs) of non-peptide CRF1 antagonists suggest that such antagonists can be constructed of three units: a hydrophobic unit (Up-Area), a proton accepting unit (Central-Area), and an aromatic unit (Down-Area). We previously presented 4-aryl-1,2,3,6-tetrahydropyridinopyrimidine derivatives including potent CRF receptor ligands 1a and 1b and proposed that the 4-aryl-1,2,3,6-tetrahydropyridino moiety might be useful as a substituent in the Up-Area. Our interest shifted to 5-aryl-1,2,3,6-tetrahydropyridinopyrimidine derivatives 2, among which compound 2m (CRA0165) had highest affinity for CRF1 receptors (IC50=11 nM). We report here the design, synthesis and SARs of derivatives 2.