213924-62-0

Basic information

• Product Name: 1H-Indene-1-methanol, 1-amino-2,3-dihydro-
• Synonyms: 1H-Indene-1-methanol, 1-amino-2,3-dihydro-;(1-aMino-2,3-dihydro-1H-inden-1-yl)Methanol
• CAS NO: 213924-62-0
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.22
• Mol File: 213924-62-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 102-103 °C
• Boiling Point: 288.8±23.0 °C(Predicted)
• Appearance: /
• Density: 1.140±0.06 g/cm3(Predicted)
• PKA: 14.74±0.10(Predicted)
• CAS DataBase Reference: 1H-Indene-1-methanol, 1-amino-2,3-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indene-1-methanol, 1-amino-2,3-dihydro-(213924-62-0)
• EPA Substance Registry System: 1H-Indene-1-methanol, 1-amino-2,3-dihydro-(213924-62-0)

Safety Data

• Hazardous Substances Data: 213924-62-0(Hazardous Substances Data)

Upstream product

• 3927-71-7 1-amino-2,3-dihydro-1H-indene-1-carboxylic acid 
• 83-33-0 inden-1-one 
• 135498-85-0 m-Nitro-indane 
• 213924-61-9 (1-Nitro-indan-1-yl)-methanol 

Downstream Products

• 943780-31-2 4-(4-aminophenylthio)-N-(1-(hydroxymethyl)-2,3-dihydro-1H-inden-1-yl)-3-(7-isopropylpyrido[2,3-d]pyrimidin-4-ylamino)benzamide 
• 213924-73-3 5',5'-dimethyl-4'-[((R)-1-phenylethyl)carbamoyl]spiro[indan-1,3'-morpholine] 
• 213924-74-4 5',5'-dimethyl-4'-[((R)-1-phenylethyl)carbamoyl]spiro[indan-1,3'-morpholine] 
• 213924-68-6 3',3'-dimethyl-2'-phenylthiospiro(indan-1,3'-morpholine) 

Relevant articles and documents

Nickel-catalyzed cross-electrophile coupling of aryl bromides and cyclic secondary alkyl bromides with spiro-bidentate-pyox ligands

The cross-electrophile coupling of aryl bromides and cyclic secondary alkyl bromides catalyzed by nickel/spiro-bidentate-pyox ligands with lithium chloride as the additive for the Csp2-Csp3bond formation was reported. The reaction could tolerate functional groups such as sulfonamide, ester, aldehyde, ketone, protected indolyl, tert-butoxycarbonyl, aryl nitriles and aryl chloride. Various aryl-cyclic secondary alkyl Csp2-Csp3bond products were synthesized under optimal reaction conditions (19 examples).

Synthesis of Chiral Nitroxides and an Unusual Racemization Reaction

Lai's protocol for the synthesis of nitroxides has been extended to the synthesis of several new chiral piperazine and morpholine nitroxides. This strategy utilizes the Bargellini reaction as the key bond-forming step. Several optically pure nitroxides incorporating α-aromatic and α-spiro centers were prepared by this route. These chiral nitroxides will be of interest as enantioselective oxidants, as traps for prochiral radicals, and in the preparation of new materials. One of these nitroxides, compound 43, was found to racemize under mild oxidizing conditions. The mechanism for this unusual racemization reaction was investigated.