213970-73-1

Upstream product

• 144735-54-6 1-ethynyl-4-(benzyloxy)-3-methoxybenzene 

Downstream Products

• 213970-74-2 2-(4-Benzyloxy-3-methoxy-phenyl)-5-((E)-2-ethoxycarbonyl-vinyl)-7-methoxy-benzofuran-3-carboxylic acid methyl ester 
• 213970-70-8 5-(2-(ethoxycarbonyl)-E-ethenyl)-7-methoxy-2-(3-methoxy-4-benzyloxyphenyl)benzofuran 
• 135040-83-4 5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)-3-benzo[b]furan-carbaldehyde 
• 70610-22-9 2-(3-methoxy-4-hydroxyphenyl)-3-methoxycarbonyl-5-(3-hydroxypropyl)-7-methoxybenzo[b]furan 
• 242474-37-9 5-(2-Ethoxycarbonyl-ethyl)-2-(4-hydroxy-3-methoxy-phenyl)-7-methoxy-benzofuran-3-carboxylic acid methyl ester 
• 213970-71-9 2-(p-hydroxy-m-methoxyphenyl)-7-methoxy-5-(carbethoxy-1-propen-1-yl)benzo[b]furan 
• 156398-61-7 (E)-2-(4-hydroxy-3-methoxyphenyl)-5-(3-hydroxyprop-1-enyl)-7-methoxybenzofuran 

Relevant academic research and scientific papers

Synthesis of 2-substituted 3-acylbenzo[b]furans via the palladium catalysed carbonylative cyclisation of ortho-hydroxytolans

A palladium-catalysed cyclisation with concomitant carbonylation via insertion of carbon monoxide was used to prepare several potential adenosine antagonists possessing a benzo[b]furan skeleton with a formyl group in the 3-position.

Synthesis of natural products possessing a benzo[b]furan skeleton

A related synthetic strategy has been used to prepare two natural products XH-14 and ailanthoidol) which possess a benzo[b]furan skeleton. The synthesis of XH-14 involved the use of a palladium-catalyzed cyclization with concomitant carbonylation via insertion of carbon monoxide to introduce regioselectively a formyl group in the 3-position.