21399-33-7

Basic information

• Product Name: 4-METHYLACETOPHENONE AZINE
• Synonyms: 4-METHYLACETOPHENONE AZINE;NSC 122706;NSC 92829;p-Methylacetophenone azine;1-(4-Methylphenyl)ethanone 2-[1-(4-methylphenyl)ethylidene]hydrazone;4,4'-Dimethylacetophenone azine
• CAS NO: 21399-33-7
• Molecular Formula: C₁₈H₂₀N₂
• Molecular Weight: 264.36
• Product Categories: Aromatic Acetophenones & Derivatives (substituted)
• Mol File: 21399-33-7.mol
• Article Data: 9

Chemical Properties

• Melting Point: 90-91 °C
• Boiling Point: 361.6°Cat760mmHg
• Flash Point: 164.8°C
• Appearance: /
• Density: 0.97g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.545
• PKA: 7?+-.0.50(Predicted)
• CAS DataBase Reference: 4-METHYLACETOPHENONE AZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYLACETOPHENONE AZINE(21399-33-7)
• EPA Substance Registry System: 4-METHYLACETOPHENONE AZINE(21399-33-7)

Safety Data

• Hazardous Substances Data: 21399-33-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H20N2/c1-13-5-9-17(10-6-13)15(3)19-20-16(4)18-11-7-14(2)8-12-18/h5-12H,1-4H3/b19-15+,20-16u

Upstream product

• 69217-53-4 t-butyl β-methyl-β-(p-methylphenyl)glycidate 
• 81313-47-5 1,1'-dichloro-1,1'-bis(4-methylphenyl)-1,1'-azoethane 
• 60672-33-5 4-methyl-N'-(1-(p-tolyl)ethylidene)benzenesulfonohydrazide 
• 2089-33-0 4-methylacethophenone oxime 
• 122-00-9 para-methylacetophenone 
• 64252-52-4 1-(1-diazoethyl)-4-methylbenzene 

Downstream Products

• 21399-23-5 2,5-di(4-methylphenyl)-1H-pyrrole 
• 34102-87-9 3,6-bis(4-methylphenyl)pyridazine 
• 104891-44-3 1-methyl-2,5-bis(4-methylphenyl)-pyrrole 
• 104891-39-6 3,6-di-(p-tolyl)dihydropyridazine 
• 5337-93-9 4'-methylpropiophenone 
• 91854-79-4 1-imino-1-(p-methylphenyl)ethane 
• 113522-06-8 1,6-dimethyl-4-(p-methylphenyl)phthalazine 
• 113522-04-6 1,6-dimethyl-4-(p-methylphenyl)dihydrophthalazine 
• 104-85-8 para-methylbenzonitrile 
• 122-00-9 para-methylacetophenone 
• 90861-44-2 (E)-1-Cyclohexyl-3-p-tolyl-3-{N'-[1-p-tolyl-eth-(E)-ylidene]-hydrazino}-allylideneamine 
• 63160-09-8 1,4-Bis(bromethyl)-1,4-di-p-tolylazinmethylen 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 622-96-8 4-methylethylbenzene 

Relevant articles and documents

Cp*Co(iii)-catalyzed annulation of azines by C-H/N-N bond activation for the synthesis of isoquinolines

Herein, an efficient, atom economic and external oxidant free approach has been disclosed for the synthesis of isoquinolines. Azines were employed for annulation reactions with alkynes via sequential C-H/N-N bond activation using an air-stable cobalt catalyst. The method takes advantage of the incorporation of both the nitrogen atoms of azines into the desired isoquinoline products, offering the highest atom economy. In addition, the developed protocol works under external oxidant as well as silver salt free conditions. Furthermore, the established methodology features a relatively broad substrate scope with high product yields and scalability up to the gram level.

Cs2CO3-mediated decomposition of N-tosylhydrazones for the synthesis of azines under mild conditions

Abstract: A facile, environmentally and efficient Cs2CO3-mediated decomposition of N-tosylhydrazones reaction has been developed for the synthesis of functionalized azines under mild conditions. This method offers broad substrate scope, occurs as additive-free, without strong base conditions, utilizes readily available reactants, and forms products in good to high yields. Graphical Abstract: [Figure not available: see fulltext.]

Copper-catalyzed N-N bond formation by homocoupling of ketoximes via n-o bond cleavage: Facile, mild, and efficient synthesis of azines

A facile, mild, and efficient copper-catalyzed homocoupling of ketoximes involving N-O bond cleavage in the presence of sodium bisulfite (NaHSO has been developed. This reaction shows good functional group tolerance and affords a broad scope of azines in high yields.