213993-30-7Relevant academic research and scientific papers
HETEROCYCLIC COMPOUNDS AND USE THEREOF AS MODULATORS OF TYPE III RECEPTOR TYROSINE KINASES
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Paragraph 0783; 0790, (2016/08/03)
Provided herein are heterocyclic compounds for treatment of CSF1R, FLT3, KIT, and/or PDGFRβ kinase mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.
Stereoselective synthesis and Cytoselective toxicity of Monoterpene-fused 2-Imino-1,3-Thiazines
Szakonyi, Zsolt,Zupk, Istvan,Sillanp??, Reijo,Fül?p, Ferenc
, p. 15918 - 15937 (2015/01/08)
Starting from pinane-, apopinane- and carane-based 1,3-amino alcohols obtained from monoterpene-based ?-amino acids, a library of monoterpene-fused 2-imino-1,3-Thiazines as main products and 2-Thioxo-1,3-oxazines as side-products were prepared via two- or
Structure-enantioselectivity effects in 3,4-dihydropyrimido[2,1-b] benzothiazole-based isothioureas as enantioselective acylation catalysts
Belmessieri, Dorine,Joannesse, Caroline,Woods, Philip A.,MacGregor, Callum,Jones, Caroline,Campbell, Craig D.,Johnston, Craig P.,Duguet, Nicolas,Concellon, Carmen,Bragg, Ryan A.,Smith, Andrew D.
experimental part, p. 559 - 570 (2011/03/16)
The catalytic activity and enantioselectivity in the kinetic resolution of (±)-1-naphthylethanol with a range of structurally related 3,4-dihydropyrimido[2,1-b]benzothiazole-based catalysts is examined. Of the isothiourea catalysts screened, (2S,3R)-2-phenyl-3-isopropyl substitution proved optimal, giving good levels of selectivity in the kinetic resolution of a number of secondary alcohols (S values up to >100 at ～50% conversion). Low catalyst loadings (0.10-0.25 mol%) of the optimal isothiourea can be used to generate enantiopure alcohols (>99% ee) in good yields.
