213999-55-4

Basic information

• Product Name: 3-{(1R,2S)-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-2-isoquinolinio}propyl-1-sulfate
• Synonyms: 3-{(1R,2S)-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-2-isoquinolinio}propyl-1-sulfate
• CAS NO: 213999-55-4
• Molecular Weight: 525.62
• Mol File: 213999-55-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-{(1R,2S)-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-2-isoquinolinio}propyl-1-sulfate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-{(1R,2S)-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-2-isoquinolinio}propyl-1-sulfate(213999-55-4)
• EPA Substance Registry System: 3-{(1R,2S)-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-2-isoquinolinio}propyl-1-sulfate(213999-55-4)

Safety Data

• Hazardous Substances Data: 213999-55-4(Hazardous Substances Data)

Upstream product

• 1073-05-8 1,3,2-dioxathiane 2,2-dioxide 

Relevant articles and documents

Synthesis of Ultra-Short-Acting Neuromuscular Blocker GW 0430: A Remarkably Stereo- and Regioselective Synthesis of Mixed Tetrahydroisoquinolinium Chlorofumarates

(Matrix Presented) The stereo- and regioselective synthesis of ultra-short-acting nondepolarizing neuromuscular blocker GW 0430 (5a) is de scribed. Key steps involved the enantioselective transfer hyrogenation of imine 8 employing Noyori's catalyst, the stereoselective catallization and methanolysis of trans-betains 11 and 12, and the stereo- and regioselective trans elimination of hydrogen chloride 'from 14. The latter transformation allowed complete control of the position of the chloro substituent and stereochemistry at the double bond of the linker in 15.