2140-69-4

Basic information

• Product Name: 3-METHYL URIDINE
• Synonyms: Nsc 246077;Uridine, 3-methyl- (8ci)(9ci)
• CAS NO: 2140-69-4
• Molecular Formula: C₁₀H₁₄N₂O₆
• Molecular Weight: 258.23
• Mol File: 2140-69-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 108-110 °C
• Boiling Point: 501.1°Cat760mmHg
• Flash Point: 256.8°C
• Appearance: /
• Density: 1.605g/cm³
• Vapor Pressure: 3.86E-12mmHg at 25°C
• Refractive Index: 1.636
• PKA: 13.26±0.70(Predicted)
• CAS DataBase Reference: 3-METHYL URIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL URIDINE(2140-69-4)
• EPA Substance Registry System: 3-METHYL URIDINE(2140-69-4)

Safety Data

• Hazardous Substances Data: 2140-69-4(Hazardous Substances Data)

Usage

Uses

3-Methyluridine can be used in biological and analytical studies of comprehensive profiling of ribonucleosides modification by affinity zirconium oxide-?silica composite monolithic column online solid-?phase microextraction - mass spectrometry analysis.

InChI:InChI=1/C10H14N2O6/c1-11-6(14)2-3-12(10(11)17)9-8(16)7(15)5(4-13)18-9/h2-3,5,7-9,13,15-16H,4H2,1H3

Upstream product

• 1899-02-1 trimethylphenylammonium hydroxide 
• 65-46-3 CYTIDINE 
• 18412-81-2 dodecyl-dimethylsulphonium iodide 
• 58-96-8 β-D/L-uridine 
• 107-71-1 tert-butyl peroxyacetate 
• 58-96-8 uridine 
• 684-93-5 1-methyl-1-nitrosourea 

Downstream Products

• 58-96-8 uridine 
• 661471-82-5 5'-O-(4,4'-dimethoxytrityl)-3-methyl-2'-O-[[(triisopropylsilyl)oxy]methyl]uridine 
• 179762-46-0 5'-O-(4,4'-dimethoxytrityl)-3-methyluridine 
• 608-34-4 3-methyluracil 
• 80973-34-8 C₁₆H₂₄N₄O₉ 
• 80973-33-7 C₂₄H₃₃N₃O₈ 

Relevant articles and documents

Noncanonical RNA Nucleosides as Molecular Fossils of an Early Earth—Generation by Prebiotic Methylations and Carbamoylations

The RNA-world hypothesis assumes that life on Earth started with small RNA molecules that catalyzed their own formation. Vital to this hypothesis is the need for prebiotic routes towards RNA. Contemporary RNA, however, is not only constructed from the four canonical nucleobases (A, C, G, and U), it also contains many chemically modified (noncanonical) bases. A still open question is whether these noncanonical bases were formed in parallel to the canonical bases (chemical origin) or later, when life demanded higher functional diversity (biological origin). Here we show that isocyanates in combination with sodium nitrite establish methylating and carbamoylating reactivity compatible with early Earth conditions. These reactions lead to the formation of methylated and amino acid modified nucleosides that are still extant. Our data provide a plausible scenario for the chemical origin of certain noncanonical bases, which suggests that they are fossils of an early Earth.

SELECTIVE METHYLATION OF NUCLEOSIDES

-