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(2R,3S)-1,4-bis(aziridin-1-yl)butane-2,3-diol, also known as Busulfan, is a bifunctional alkylating agent that is a synthetic derivative of dimethylbusulfan. It is characterized by its ability to bind to DNA and induce cross-links between DNA strands, which inhibits DNA replication and cell proliferation.

21401-28-5

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21401-28-5 Usage

Uses

Used in Cancer Treatment:
(2R,3S)-1,4-bis(aziridin-1-yl)butane-2,3-diol is used as a conditioning agent in the preparation for hematopoietic stem cell transplantation. It is particularly effective in treating certain types of cancer, such as leukemia, due to its ability to inhibit cell proliferation.
Used in Pharmaceutical Industry:
(2R,3S)-1,4-bis(aziridin-1-yl)butane-2,3-diol is used as a pharmaceutical agent for its alkylating properties. Its effectiveness in treating cancer has led to its use in the development of medications for various types of cancer.
However, it is important to note that the use of (2R,3S)-1,4-bis(aziridin-1-yl)butane-2,3-diol is associated with significant toxicity and adverse effects, such as myelosuppression, infertility, and an increased risk of secondary malignancies. As a result, its use is carefully monitored and managed by healthcare professionals to ensure patient safety and optimize therapeutic outcomes.

Check Digit Verification of cas no

The CAS Registry Mumber 21401-28-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,4,0 and 1 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 21401-28:
(7*2)+(6*1)+(5*4)+(4*0)+(3*1)+(2*2)+(1*8)=55
55 % 10 = 5
So 21401-28-5 is a valid CAS Registry Number.

21401-28-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name meso-2,3-Butanediol, 1,4-bis(1-aziridinyl)-

1.2 Other means of identification

Product number -
Other names meso-1,4-bis-aziridin-1-yl-butane-2,3-diol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:21401-28-5 SDS

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