214055-11-5

Basic information

• Product Name: 5-chloro-3-fluoropicolinaldehyde
• Synonyms: 5-chloro-3-fluoropicolinaldehyde;5-chloro-3-fluoropyridine-2-carbaldehyde
• CAS NO: 214055-11-5
• Molecular Formula: C6H3ClFNO
• Molecular Weight: 159.55
• Mol File: 214055-11-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 188.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.444±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -1.03±0.10(Predicted)
• CAS DataBase Reference: 5-chloro-3-fluoropicolinaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-3-fluoropicolinaldehyde(214055-11-5)
• EPA Substance Registry System: 5-chloro-3-fluoropicolinaldehyde(214055-11-5)

Safety Data

• Hazardous Substances Data: 214055-11-5(Hazardous Substances Data)

Usage

General Description

5-chloro-3-fluoropicolinaldehyde is a chemical compound with the molecular formula C6H3ClFNOS. It is a yellow solid that is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. 5-chloro-3-fluoropicolinaldehyde is a derivative of pyridine and has a chloro and fluoro group attached to the aromatic ring, as well as an aldehyde functional group. It has a wide range of applications in the chemical and pharmaceutical industries due to its versatility in various organic reactions. However, it should be handled with care as it may be harmful if swallowed, inhaled, or in contact with skin.

Upstream product

• 207994-08-9 5-chloro-3-fluoro-2-pyridinecarboxylic acid 
• 1600511-96-3 5-chloro-3-fluoro-N-methoxy-N-methylpicolinamide 
• 214055-12-6 (5-chloro-3-fluoropyridin-2-yl)methanol 
• 207994-06-7 3-fluoro-5-chloro-2-pyridinecarboxylic acid ethyl ester 

Downstream Products

• 1600535-78-1 (Z)-N-(5-(5-(5-chloro-3-fluoro-N'-hydroxypicolinimidamido)-2-fluorophenyl)-2,2,5-trimethyl-1,1-dioxido-5,6-dihydro-2H-1,4-thiazin-3-yl)benzamide 
• 1600511-95-2 N-(5-(5-((6-chloroisoxazolo[4,5-b]pyridin-3-yl)amino)-2-fluorophenyl)-2,2,5-trimethyl-1,1-dioxido-5,6-dihydro-2H-1,4-thiazin-3-yl)benzamide 
• 1600507-25-2 N-(3-((3R)-5-amino-3,6,6-trimethyl-1,1-dioxido-3,6-dihydro-2H-1,4-thiazin-3-yl)-4-fluorophenyl)-6-chloroisoxazolo[4,5-b]pyridin-3-amine 

Relevant articles and documents

PLASMA KALLIKREIN INHIBITORS AND USES THEREOF

The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.

Pharmaceutical compositions (by machine translation)

[Problem] imidazole compound or its pharmacologically acceptable salt in the melanocortin receptor activity that operates as an active ingredient of a pharmaceutical composition comprising. "I" general formula [a]" Formula, the aryl group may be substituted A ring represents a; R1 Represents a hydrogen atom, or an alkyl group which may be substituted represented; R2 Represents a hydrogen atom, a halogen atom or represents a; R3 The alkyl group may be substituted " represented by the imidazole compound, its pharmacologically acceptable salt as an active ingredient in a pharmaceutical composition. [Drawing] no (by machine translation)

TRICYCLIC IMIDAZOLE COMPOUNDS AS INHIBITORS OF TRYPTOPHAN HYDROXYLASE

The present invention relates to compounds of the formula (I), wherein R1a, R1b, R2, R3, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to thei