214078-94-1

Basic information

• Product Name: 1,8-bis(2′-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane
• Synonyms: 1,8-bis(2′-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane
• CAS NO: 214078-94-1
• Molecular Weight: 382.552
• Mol File: 214078-94-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,8-bis(2′-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane(CAS DataBase Reference)
• NIST Chemistry Reference: 1,8-bis(2′-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane(214078-94-1)
• EPA Substance Registry System: 1,8-bis(2′-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane(214078-94-1)

Safety Data

• Hazardous Substances Data: 214078-94-1(Hazardous Substances Data)

Upstream product

• 4377-33-7 2-chloromethylpyridine 

Relevant articles and documents

New synthesis of trans-disubstituted cyclam macrocycles - Elucidation of the disubstitution mechanism on the basis of x-ray data and molecular modeling

A new way to synthesize trans-disubstituted cyclam tetraazamacrocycles 1 is reported. The synthesis proceeds in three steps via the tricyclic 1,4,8,11-tetraazatricyclo-[9.3.1.14,8]hexadecane system 2, which can be selectively dialkylated and hydrolyzed under basic conditions to give the final product 1. An understanding of the reactivity, based on the X-ray experimental electrostatic potential and molecular modeling of the 1,4,8,11-tetraazatricyclo-[9.3.1.14,8]hexadecane macrotricycle, has permitted the elucidation of a new reaction pathway leading to the trans-disubstituted cyclam.