2141-09-5

Basic information

• Product Name: (+)-MAGNOFLORINE IODIDE
• Synonyms: MAGNOFLORINE;(+)-MAGNOFLORINE IODIDE;MAGNOFLORINE IODIDE, (+)-;1,11-dihydroxy-2,10-dimethoxy-6-methyl-6a-alpha-aporphiniu;escholin;escholine;g)quinolinium,5,6,6a,7-tetrahydro-1,11-dihydroxy-2,10-dimethoxy-4h-dibenzo(d;THALICTRIN
• CAS NO: 2141-09-5
• Molecular Formula: C20H24INO4
• Molecular Weight: 469.31
• Product Categories: Alkaloids
• Mol File: 2141-09-5.mol
• Article Data: 0

Chemical Properties

• Melting Point: 252℃
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: (+)-MAGNOFLORINE IODIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-MAGNOFLORINE IODIDE(2141-09-5)
• EPA Substance Registry System: (+)-MAGNOFLORINE IODIDE(2141-09-5)

Safety Data

• Hazardous Substances Data: 2141-09-5(Hazardous Substances Data)

Usage

Description

Different sources of media describe the Description of 2141-09-5 differently. You can refer to the following data:
1. A wide variety of species contain this quaternary alkaloid which is widespread among the families, Aquilegia, Magnolia and Michelia. It has been isolated and characterized as the iodide, m.p. 248-9°C (dec.); [0:11>5 + 200.1° (MeOH). The optically inactive base also yields an iodide which crystallizes with 1.5 H20, m.p. 243°C (dec.).
2. Magnoflorine is an alkaloid and a major constituent of S. acutum that has diverse biological activities. It reduces hemolysis induced by lysophosphatidylcholine (LPC), but not NaCl, in a rat erythrocyte suspension when used at concentrations ranging from 0.01 to 10 μM. Magnoflorine (10 μM) induces intracellular chloride influx in neuroblastoma cells, an effect that is reversed by the GABAA receptor antagonist bicuculline . It reduces TNF-α-induced NF-κB expression as well as production of IL-6 and IL-8 in BEAS-2B cells. In vivo, magnoflorine (20 mg/kg, i.p.) improves short- and long-term memory acquisition in a passive avoidance test in a mouse model of scopolamine-induced memory impairment.

References

Nakano., Chem. Pharm. Bull. (Tokyo), 2, 329 (1954) Tomita, Kikkawa.,J. Pharm. Soc., Japan, 77, 195 (1957) Gopinath et aI., J. Sci. Ind. Res., 18B, 444 (1959) Ishii, Harada.,J. Pharm. Soc., Japan, 81,238 (1961) Yang, Lu, Hsiao., ibid, 82,794,816 (1962) Yang, Lu, Hsiao., ibid, 83,216 (1963)

InChI:InChI=1/C20H23NO4/c1-21(2)8-7-12-10-15(25-4)20(23)18-16(12)13(21)9-11-5-6-14(24-3)19(22)17(11)18/h5-6,10,13H,7-9H2,1-4H3,(H-,22,23)/p+1