21412-35-1

Basic information

• Product Name: 5-(3-phenyl-propyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one
• Synonyms: 5-(3-phenyl-propyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one
• CAS NO: 21412-35-1
• Molecular Weight: 246.333
• Mol File: 21412-35-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(3-phenyl-propyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-phenyl-propyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one(21412-35-1)
• EPA Substance Registry System: 5-(3-phenyl-propyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one(21412-35-1)

Safety Data

• Hazardous Substances Data: 21412-35-1(Hazardous Substances Data)

Upstream product

• 17734-38-2 ethyl 5-phenylpentanoate 
• 109-94-4 formic acid ethyl ester 

Relevant articles and documents

PYRIMIDONE DERIVATIVES

Compounds of the formula (I) STR1 in which R 1 and R. sub.2 each may represent hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aralkyl, or alkyl, substituted by hydroxy, C 1-3 alkoxy, amino, C 1-3 alkylamino or di-C 1-3 alkylamino or R 1 and R 2 together with the nitrogen atom to which they are attached form an alicyclic heterocyclic ring which may be unsubstituted or may be substituted by one or more C 1-3 alkyl groups or a hydroxy group and/or may contain another heteroatom are described.Alk is a straight lower alkylene chain,Q is a furan or thiophen ring, the furan ring optionally bearing a further substituent R 5 adjacent to the group R 1 R 2 NAlk--or Q represents a benzene ring. R 5 represents halogen or C 1-3 alkyl which may be substituted by a hydroxy or C 1-3 alkoxy group;X represents--CH 2--,--O--or--S--;n represents zero or 1;m represents 2, 3 or 4;Y represents =O or =S;R 3 represents hydrogen in which case R 4 represents methyl or R 3 represents--(CH 2) p V(CH 2) q Ar, phenyl, or alkyl in which case R. sub.4 represents hydrogen;V represents--CH 2--,--O--, or--S--;p represents zero, 1, 2 or 3; q represents zero, 1, 2 or 3;the sum of p+q being 3 or less;Ar represents an aromatic carbocyclic or heterocyclic ring being optionally substituted by at least one C 1-3 alkyl, C 1-3 alkoxy C 1-3 alkyl, hydroxy, C 1-3 alkoxy, methylenedioxy, halogen, trifluoromethyl or di-C 1-3 alkylamino group; except that when n is zero and X is oxygen then Q represents a benzene or thiophen ring. The compounds of formula (I) have pharmacological activity as selective histamine H 2-antagonists.