214124-19-3Relevant academic research and scientific papers
Novel inhibitors of neuronal nitric oxide synthase with potent antioxidant properties.
Auvin, Serge,Auguet, Michel,Navet, Edith,Harnett, Jeremiah J,Viossat, Isabelle,Schulz, Jocelyne,Bigg, Dennis,Chabrier, Pierre E
, p. 209 - 212 (2007/10/03)
A series of hybrid compounds possessing an nNOS pharmacophore linked to an antioxidant fragment has been synthesized. Among them, compound 8d, a propofol derivative, displayed the greatest dual potencies against nNOS (IC(50)=0.12 microM) and lipid peroxidation (IC(50)=0.4 microM) accompanied with e/nNOS selectivity (67.5). This shows that nNOS was able to accommodate very bulky groups such as di-tert-butyl or di-iso-propyl phenol in its active site.
