214139-86-3

Basic information

• Product Name: N-CYCLOPROPYL L-VALINAMIDE
• Synonyms: N-CYCLOPROPYL L-VALINAMIDE;N~1~-cyclopropyl-L-valinamide
• CAS NO: 214139-86-3
• Molecular Formula: C₈H₁₆N₂O
• Molecular Weight: 156.22544
• Mol File: 214139-86-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-CYCLOPROPYL L-VALINAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-CYCLOPROPYL L-VALINAMIDE(214139-86-3)
• EPA Substance Registry System: N-CYCLOPROPYL L-VALINAMIDE(214139-86-3)

Safety Data

• Hazardous Substances Data: 214139-86-3(Hazardous Substances Data)

Upstream product

• 13734-41-3 t-Boc-L-valine 
• 1350980-67-4 C₁₃H₂₄N₂O₃ 

Downstream Products

• 1350980-63-0 cyclopropyl N-(1-oxyl-4'-demethyl-4-deoxypodophyllic)-L-valine amide 

Relevant articles and documents

Carbamates of 4′-demethyl-4-deoxypodophyllotoxin: Synthesis, cytotoxicity and cell cycle effects

In an attempt to generate compounds with superior bioactivity and reduced toxicity, 12 carbamates of 4′-demethyl-4-deoxypodophyllotoxin, N-(1-oxyl-4′-demethyl- 4-deoxypodophyllic)-α-amino acids amides, were synthesized and evaluated for antiproliferative activity and cell cycle effects. These synthesized compounds proved to be more hydrophilic, as well as improved or comparable in vitro cytotoxicities against four cell lines (A-549, HeLa, SiHa, and HL-60) compared with either parent DPT or anti-cancer drug VP-16. Furthermore, flow cytometric analysis exhibited that N-(1-oxyl-4′- demethyl-4-deoxypodophyllic)-d-α-methine amide (15f) induced cell cycle arrest in the G2/M phase in A-549 cells.