214151-23-2Relevant articles and documents
Rational design, synthesis, and X-ray structure of selective noncovalent thrombin inhibitors
Wagner, Jürgen,Kallen, J?rg,Ehrhardt, Claus,Evenou, Jean-Pierre,Wagner, Dieter
, p. 3664 - 3674 (2007/10/03)
We have designed, synthesized, and tested in vitro a novel class of noncovalent thrombin inhibitors. The main feature of these inhibitors is a 6,5-fused bicyclic core structure that fills the S2 pocket of the active site of thrombin. The bicycl