21416-53-5 Usage
Uses
Used in Pharmaceutical Industry:
Picrotin is used as a GABAa receptor antagonist for its ability to selectively target and inhibit glycine receptors. This property makes it a valuable compound in the development of drugs aimed at modulating the activity of these receptors, which can be beneficial in treating various neurological and psychiatric disorders.
Used in Research and Development:
In the field of research, Picrotin is utilized as a tool to study the function and role of glycine receptors in the central nervous system. Its selective inhibition of GlyRs allows scientists to better understand the underlying mechanisms of these receptors and their potential involvement in different pathological conditions.
Used in Neuropharmacology:
Picrotin is employed as a research compound in neuropharmacology to investigate the interactions between glycine receptors and other neurotransmitter systems, such as GABA receptors. This knowledge can contribute to the development of novel therapeutic strategies for conditions like epilepsy, where both GlyRs and GABA receptors play crucial roles in regulating neuronal excitability.
Check Digit Verification of cas no
The CAS Registry Mumber 21416-53-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,4,1 and 6 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 21416-53:
(7*2)+(6*1)+(5*4)+(4*1)+(3*6)+(2*5)+(1*3)=75
75 % 10 = 5
So 21416-53-5 is a valid CAS Registry Number.
InChI:InChI=1/C15H18O7/c1-12(2,18)6-7-10(16)20-8(6)9-13(3)14(7,19)4-5-15(13,22-5)11(17)21-9/h5-9,18-19H,4H2,1-3H3/t5-,6+,7-,8-,9-,13-,14-,15+/m1/s1
21416-53-5Relevant academic research and scientific papers
Synthesis of (-)-Picrotoxinin by Late-Stage Strong Bond Activation
Burdge, Hannah E.,Crossley, Steven W. M.,Lambrecht, Michael J.,Shenvi, Ryan A.,Tong, Guanghu
, (2020/07/08)
We report a concise, stereocontrolled synthesis of the neurotoxic sesquiterpenoid (-)-picrotoxinin (1, PXN). The brevity of the route is due to regio-and stereoselective formation of the [4.3.0] bicyclic core by incorporation of a symmetrizing geminal dim
Stereoselective Total Synthesis of (-)-Picrotoxnin and (-)-Picrotin
Miyashita, Masaaki,Suzuki, Toshio,Yoshikoshi, Akira
, p. 3728 - 3734 (2007/10/02)
The stereoselective total synthesis of (-)-picritoxnin (1) and (-)-picrotin (2), starting from (+)-5β-hydroxycarvone (3), is described.Eight contiguous asymmetric centers on a cis-fused hydrindane ring system were stereoselectively prepared via three key
