214198-25-1Relevant articles and documents
Total synthesis of (-)-bafilomycin A1
Scheidt, Karl A.,Bannister, Thomas D.,Tasaka, Akihiro,Wendt, Michael D.,Savall, Brad M.,Fegley, Glenn J.,Roush, William R.
, p. 6981 - 6990 (2002)
A highly stereoselective total synthesis of (-)-bafilomycin A1, the naturally occurring enantiomer of this potent vacuolar ATPase inhibitor, is described. The synthesis features the highly stereoselective aldol reaction of methyl ketone 8b and