21423-81-4

Basic information

• Product Name: 3-CHLORO-4-METHYLBENZONITRILE
• Synonyms: Benzonitrile, 3-chloro-4-methyl-;3-CHLORO-P-TOLUNITRILE;3-CHLORO-4-TOLUNITRILE;3-CHLORO-4-METHYLBENZONITRILE;3-chloro-p-toluonitrile;3-Chloro-4-methylbenzonitrile 98%;3-chloro-4-methyl-benzenecarbonitrile;3-Chloro-p-tolunitrile, 2-Chloro-4-cyanotoluene
• CAS NO: 21423-81-4
• Molecular Formula: C₈H₆ClN
• Molecular Weight: 151.59
• EINECS: 244-381-3
• Product Categories: Aromatic Nitriles
• Mol File: 21423-81-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 45-48 °C(lit.)
• Boiling Point: 106°C/6mm
• Flash Point: 183 °F
• Appearance: white to light yellow crystal powder
• Density: 1.19
• Vapor Pressure: 0.043mmHg at 25°C
• Refractive Index: 1.553
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• CAS DataBase Reference: 3-CHLORO-4-METHYLBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4-METHYLBENZONITRILE(21423-81-4)
• EPA Substance Registry System: 3-CHLORO-4-METHYLBENZONITRILE(21423-81-4)

Safety Data

• Hazard Codes: Xi,F
• Statements: 11
• Safety Statements: 36
• RIDADR: UN 1325 4.1/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 21423-81-4(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

Uses

3-Chloro-4-methylbenzonitrile may be used in chemical synthesis studies.

InChI:InChI=1/C8H6ClN/c1-6-2-3-7(5-10)4-8(6)9/h2-4H,1H3

Upstream product

• 39652-32-9 (3-chloro-4-methylphenyl) methanol 
• 557-21-1 zinc(II) cyanide 
• 95-49-8 2-methylchlorobenzene 
• 95-74-9 3-chloro-p-toluidine 
• 863431-87-2 dimethyl 2-(4-cyano-2-chlorophenyl)-1,3-propanedioate 
• 67952-93-6 1-(3-chloro-4-methylphenyl)methanamine 
• 143-33-9 sodium cyanide 

Downstream Products

• 21924-83-4 4-(bromomethyl)-3-chlorobenzonitrile 
• 177660-65-0 2-(3-chloro-4-methylphenyl)-1-[4-(methylsulfonyl)phenyl]-4-(trifluoromethyl)-1H-imidazole 
• 177662-28-1 2-(3-chloro-4-methylphenyl)-4-hydroxy-1-[4-(methylsulfonyl)phenyl]-4-(trifluoromethyl)-4,5-dihydro-1H-imidazole 
• 16013-11-9 3-(3-chloro-4-methylphenyl)-1,2,4-oxadiazole 
• 1416978-62-5 (E)-N-(2-Chloro-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)benzyl)pyridin-2-amine 
• 1416978-50-1 (E)-1-(2-Chloro-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)benzyl)-3-ethylurea 
• 1416978-26-1 (E)-N-(2-Chloro-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)benzyl)acetamide 
• 1416980-49-8 N-(2-chloro-4-vinylbenzyl)pyridine-2-amine 
• 1416980-48-7 3-chloro-4-((pyridin-2-ylamino)methyl)benzaldehyde 
• 1416980-41-0 (E)-(2-chloro-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)phenyl)methanamine 
• 1416980-33-0 (E)-2-(2-chloro-4-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)benzyl)isoindoline-1,3-dione 
• 1416980-29-4 2-(2-chloro-4-vinylbenzyl)isoindoline-1,3-dione 
• 1416980-25-0 3-chloro-4-((1,3-dioxoisoindolin-2-yl)methyl)benzaldehyde 

Relevant articles and documents

Atomically Dispersed Ru on Manganese Oxide Catalyst Boosts Oxidative Cyanation

There is a strong incentive for environmentally benign and sustainable production of organic nitriles to avoid the use of toxic cyanides. Here we report that manganese oxide nanorod-supported single-site Ru catalysts are active, selective, and stable for oxidative cyanation of various alcohols to give the corresponding nitriles with molecular oxygen and ammonia as the reactants. The very low amount of Ru (0.1 wt %) with atomic dispersion boosts the catalytic performance of manganese oxides. Experimental and theoretical results show how the Ru sites enhance the ammonia resistance of the catalyst, bolstering its performance in alcohol dehydrogenation and oxygen activation, the key steps in the oxidative cyanation. This investigation demonstrates the high efficiency of a single-site Ru catalyst for nitrile production.

Preparation method of arylmethane compound

The invention discloses a preparation method of an arylmethane compound. The preparation method of the arylmethane compound I comprises that a compound I-2 undergoes a de-esterification reaction in anorganic solvent under action of calcium chloride and water at a reaction temperature of 130 DEG C to the solvent boiling point to produce the compound I, wherein R' and R respectively represent anyone of methyl, ethyl, isopropyl and t-butyl, n is 0 or 1, R1, R2, R3, R4 and R5 respectively represent H or an electron-withdrawing group and at least one of the groups is an electron-withdrawing group. The preparation method utilizes easily available raw materials, realizes a low cost, produces few three wastes, has safe processes and is suitable for industrial production.

Imidazole derivatives, compositions and use

Compounds of the formula: STR1 wherein R is (Hal)m wherein Hal represents a halogen atom and m is 1 or 2, or R is-(B1)n1 W1 wherein B1, n1 and W1 are as defined below; W and (when present) W1, which may be the same or different, each represents a carboxyl, esterified carboxyl, amide, N-C1-4 alkyl-amide, N,N-di-(C1-4 alkyl)-amide, nitrile, aldehyde, amino, hydroxymethyl, or tetrazolyl group; n and (when present) n1 which may be the same or different, are each 0 or 1; and A, B and (when present) B1, which may be the same or different, each represents a straight chain or branched C1-3 alkylene or C2-3 alkenylene group. These compounds have been found to possess potent and selective inhibitory activity against thromboxane synthetase which renders the compounds useful in the treatment or prophylaxis of thrombo-embolic disorders.