214260-91-0

Upstream product

• 214260-88-5 (2S,3S,3aS,4aS,5R,8S,8aS)-5,10,10-trimethyl-2-heptyl-5,8-methanooctahydro-2H-isoxazolo[3,2-b]benzoxazole-3-carboxylic acid ethyl ester 
• 214260-89-6 (2S,3S,3aS,4aS,5R,8S,8aS)-5,10,10-trimethyl-2-heptyl-5,8-methanooctahydro-2H-isoxazolo[3,2-b]benzoxazole-3-methanol 
• 7367-88-6 ethyl (E)-2-decenate 
• 76-83-5 trityl chloride 
• 214260-90-9 (2S,3S)-3-Hydroxy-2-hydroxymethyl-decanoic acid 

Relevant academic research and scientific papers

Oxazoline N-oxide-mediated [2 + 3] cycloadditions: Application to a total synthesis of the hypocholesterolemic agent 1233A

Oxetanone 1233A 1 has been synthesized in 22 steps and 3.43% overall yield from 3-methylglutaric anhydride. Asymmetric carbon at C7 was introduced by a diastereoselective esterification of 3-methylglutaric anhydride, whereas the two asymmetric carbons at C2' and C3' were controlled by an asymmetric [2 + 3] cycloaddition using camphor-derived oxazoline N-oxide as dipole.