214261-07-1

Upstream product

• 76-83-5 trityl chloride 
• 214261-05-9 (2R,3R,3aR,4R,4aR,5S,8R,8aS,5'S,7E)-2-(5',7'-dimethyl-8'-iodo-7'-octen-1'-yl)-5,10,10-trimethyl-5,8-methanooctahydro-2H-isoxazolo[3,2-b]benzoxazole-3-methanol 
• 214260-95-4 (3R,1'R,2''RS)-3-methyl-5-(2-tetrahydropyranyloxy)pentanoic acid (1'-α-naphthyl)ethyl ester 
• 214260-94-3 (3R,1'R)-5-hydroxy-3-methylpentanoic acid (1'-α-naphthyl)ethyl ester 
• 214261-04-8 (2R,3R,3aR,4R,4aR,5S,8R,8aS,5'S,7E)-2-(5',7'-dimethyl-8'-iodo-7'-octen-1'-yl)-5,10,10-trimethyl-5,8-methanooctahydro-2H-isoxazolo[3,2-b]benzoxazole-3-carboxylic acid ethyl ester 
• 214260-96-5 (4R,2''RS)-4-methyl-6-(2-tetrahydropyranyloxy)1-hexyne 
• 214261-02-6 (6R,8E)-6,8-dimethyl-9-iodo-8-nonenal 
• 214260-98-7 (3S,5E)-6-iodo-3,5-dimethyl-5-hexen-1-ol 
• 1027832-48-9 (E)-(S)-1,6-Diiodo-2,4-dimethyl-hex-1-ene 
• 214260-99-8 (3S,5E)-6-iodo-3,5-dimethyl-5-hexenal 
• 214260-97-6 (S)-3-methylhex-5-yn-1-ol 
• 214261-03-7 (2E,10E)-(R)-11-Iodo-8,10-dimethyl-undeca-2,10-dienoic acid ethyl ester 
• 214261-00-4 2-((2E,7E)-(R)-8-Iodo-5,7-dimethyl-octa-2,7-dienyl)-[1,3]dioxolane 
• 214261-01-5 2-((E)-(R)-8-Iodo-5,7-dimethyl-oct-7-enyl)-[1,3]dioxolane 

Downstream Products

• 214261-09-3 (2R,3R,3aR,4R,4aR,5S,8R,8aS,5'S,7E)-2-(10'-(1,1)-dimethylethyloxycarbonyl-5',7',9'-trimethyl-7',9'-decadien-1'-yl)-3-[(1,1,1-triphenyl)methoxymethyl]-5,10,10-trimethyl-5,8-methanooctahydro-2H-isoxazolo[3,2-b]benzoxazole 
• 214261-11-7 (2E,4E)-(7R,12R,13R)-12-Hydroxy-3,5,7-trimethyl-13-trityloxymethyl-tetradeca-2,4-dienedioic acid 1-tert-butyl ester 
• 214261-13-9 (2E,4E)-(R)-3,5,7-Trimethyl-11-((2R,3R)-4-oxo-3-trityloxymethyl-oxetan-2-yl)-undeca-2,4-dienoic acid tert-butyl ester 

Relevant academic research and scientific papers

Oxazoline N-oxide-mediated [2 + 3] cycloadditions: Application to a total synthesis of the hypocholesterolemic agent 1233A

Oxetanone 1233A 1 has been synthesized in 22 steps and 3.43% overall yield from 3-methylglutaric anhydride. Asymmetric carbon at C7 was introduced by a diastereoselective esterification of 3-methylglutaric anhydride, whereas the two asymmetric carbons at C2' and C3' were controlled by an asymmetric [2 + 3] cycloaddition using camphor-derived oxazoline N-oxide as dipole.