214262-99-4

Basic information

• Product Name: 1-(4-FLUOROPHENYL)CYCLOPENTANECARBOXYLIC ACID, 98
• Synonyms: 1-(4-FLUOROPHENYL)CYCLOPENTANECARBOXYLIC ACID, 98;1-(4-FLUOROPHENYL)CYCLOPENTANECARBOXYLIC ACID 98%;1-(4-Fluorophenyl)cyclopentanecarboxylic acid, 98% 5GR
• CAS NO: 214262-99-4
• Molecular Formula: C12 H13 F O2
• Molecular Weight: 208.09
• Mol File: 214262-99-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 160 °C
• Boiling Point: 334.2°C at 760 mmHg
• Flash Point: 155.9°C
• Appearance: /
• Density: 1.1262 (estimate)
• Vapor Pressure: 5.15E-05mmHg at 25°C
• Refractive Index: 1.55
• Storage Temp.: 2-8°C
• PKA: 4.36±0.20(Predicted)
• CAS DataBase Reference: 1-(4-FLUOROPHENYL)CYCLOPENTANECARBOXYLIC ACID, 98(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUOROPHENYL)CYCLOPENTANECARBOXYLIC ACID, 98(214262-99-4)
• EPA Substance Registry System: 1-(4-FLUOROPHENYL)CYCLOPENTANECARBOXYLIC ACID, 98(214262-99-4)

Safety Data

• Hazardous Substances Data: 214262-99-4(Hazardous Substances Data)

Usage

Chemical Properties

pale greyish crystals

InChI:InChI=1/C12H13FO2/c13-10-5-3-9(4-6-10)12(11(14)15)7-1-2-8-12/h3-6H,1-2,7-8H2,(H,14,15)

Upstream product

• 34837-84-8 4-fluorobenzeneacetic acid methyl ester 
• 459-22-3 4-fluorophenylacetonitrile 
• 83706-50-7 1-(4-fluorophenyl)cyclopentane-1-carbonitrile 

Downstream Products

• 1332694-50-4 C₂₄H₂₈ClFN₂O₃ 

Relevant articles and documents

Amide compound and derivative thereof, preparation method, pharmaceutical composition and application thereof

The invention discloses an amide compound and derivative thereof, a preparation method, a pharmaceutical composition and application thereof. The structure of the amide compound is shown as a formula (I). The derivatives of theamide compound relate to a stereoisomer, a tautomer, a metabolite, a metabolic precursor, a prodrug, a solvate, a salt of the solvate, a crystal, a pharmaceutically acceptable salt or a mixture of the above of theamide compound. The amide compound and the derivative thereof have an efficient inhibition effect on indoleamine 2, 3-dioxygenase 1, and can be used for preparing medicines for treating indoleamine 2, 3-dioxygenase 1 mediated immunosuppression related diseases, the prepared medicine can exert the medicine effect at the molecular level and is wide in application, and the synthesis method of the compound is simple, convenient and easy to operate.

Synthesis and pharmacological evaluation of 1-Alkyl-N-[(1R)-1-(4- fluorophenyl)-2-methylpropyl]piperidine-4-carboxamide derivatives as novel antihypertensive agents

We synthesized and evaluated inhibitory activity against T-type Ca 2+ channels for a series of 1-alkyl-N- [(1R)-1-(4-fluorophenyl)-2- methylpropyl]piperidine-4-carboxamide derivatives. Structure-activity relationship studies have revealed that the isopropyl substituent at the benzylic position plays an important role in exerting potent inhibitory activity, and the absolute configuration of the benzylic position was found to be opposite that of mibefradil, which was first launched as a new class of T-type Ca2+ channel blocker. Oral administration of N- [(1R)-1-(4-fluorophenyl)-2-methylpropyl]-1-[2-(3-methoxyphenyl)ethyl] piperidine-4-carboxamide (17f) lowered blood pressure in spontaneously hypertensive rats without inducing reflex tachycardia, an adverse effect often caused by traditional L-type Ca2+ channel blockers.