214264-58-1

Upstream product

• 214264-55-8 1-{(2R,3R,3aS,9aR)-5,5,7,7-Tetraisopropyl-3-[(E)-3-(4-methyl-3,5-dioxo-[1,2,4]triazolidin-1-yl)-propenyl]-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-1H-pyrimidine-2,4-dione 
• 151384-08-6 2'-deoxy-2'-α-C-(2-propenyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 
• 199480-54-1 Acetic acid (2R,3R,3aS,9aR)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-ylmethyl ester 
• 199480-48-3 1-((2R,3R,3aS,9aR)-3-Hydroxymethyl-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 692781-24-1 2'-deoxy-2'-α-C-(acetoxymethyl)uridine 

Downstream Products

• 214264-59-2 Acetic acid (2R,3R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-ylmethyl ester 
• 199480-66-5 C₄₉H₅₂N₅O₁₉P 
• 219571-04-7 3-[(1R,3R,3aS,7aR)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-oxo-tetrahydro-2,4,6-trioxa-5λ⁵-phospha-inden-5-yloxy]-propionitrile 
• 219571-03-6 1-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-3-hydroxymethyl-tetrahydro-furan-2-yl}-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

The synthesis of 2'-homouridine, its incorporation into a dinucleoside monophosphate and hydrolytic behaviour of the dimer

An efficient route to 2'-homouridine (1), a new nucleoside analogue, is reported that is based on an one reaction. This nucleoside has been incorporated into a dinucleotide monophosphate and hydrolytic studies on the dimer show that it does not behave like a ribonucleotide.

Synthesis and transcription studies on 5'-triphosphates derived from 2'-C-branched-uridines: 2'-homouridine-5'-triphosphate is a substrate for T7 RNA polymerase.

The 5'-triphosphates of 2'-hydroxymethyluridine (2'-homouridine) and 2'-hydroxyethyluridine were prepared from the corresponding acetyl-protected nucleosides by initial phosphitylation with 2-chloro-5,6-benzo-1,2,3-dioxaphosphorin-4-one. 2'-Acetamidouridi

The synthesis of a novel 2',3'-cyclic phosphate derived from 2'- homouridine

The novel 2',3'-cyclic phosphate (1) derived from 2'-homouridine has been prepared by phosphorylation with 2-cyanoethyl N,N,N',N'- tetraisopropylphosphorodiamidite.

The synthesis of 2′-C-functionalised nucleosides for incorporation into catalytic RNA

Five 2′-C-functionalized nucleosides (1-5) have been prepared and incorporated into dinucleoside monophosphates. The effect of the functionality on the stability of the adjacent phosphodiester bond toward hydrolysis by nuclease enzymes and extremes of pH has been assessed. Copyright