21427-61-2

Basic information

• Product Name: 5-Chloro-2-hydroxy-3-nitropyridine
• Synonyms: 5-CHLORO-2-HYDROXY-3-NITROPYRIDINE;5-CHLORO-3-NITROPYRIDIN-2-OL;5-CHLORO-3-NITRO-2-PYRIDINOL;2-hydroxy-3-nitro-5-chloropyridine;5-Chloro-3-nitropyridin-2-ol, 95+%;5-Chloro-2-hydroxy-3-nitropyridine 95+%;5-Chloro-2-hydroxy-3-nitropyridine ,97%;2-Hydroxy-5-chloro-3-nitropyridine
• CAS NO: 21427-61-2
• Molecular Formula: C₅H₃ClN₂O₃
• Molecular Weight: 174.54
• EINECS: -0
• Product Categories: blocks;NitroCompounds;Pyridines;Pyridine;Chloropyridines;Halopyridines;Bases & Related Reagents;Nucleotides;Heterocycle-Pyridine series
• Mol File: 21427-61-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 234 °C
• Boiling Point: 316 °C at 760 mmHg
• Flash Point: 125.6 °C
• Appearance: yellow solid
• Density: 1.664 g/cm³
• Vapor Pressure: 0.00303mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: soluble in Dimethylformamide
• PKA: 6.31±0.10(Predicted)
• BRN: 383852
• CAS DataBase Reference: 5-Chloro-2-hydroxy-3-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-2-hydroxy-3-nitropyridine(21427-61-2)
• EPA Substance Registry System: 5-Chloro-2-hydroxy-3-nitropyridine(21427-61-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39-39-36-37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 21427-61-2(Hazardous Substances Data)

Usage

Chemical Properties

White to light brown solid

Uses

5-Chloro-2-hydroxy-3-nitropyridine (cas# 21427-61-2) is a compound useful in organic synthesis.

InChI:InChI=1/C5H3ClN2O3/c6-3-1-4(8(10)11)5(9)7-2-3/h1-2H,(H,7,9)

Upstream product

• 1072-98-6 5-chloro-2-pyridylamine 
• 5409-39-2 2-amino-5-chloro-3-nitropyridine 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 
• 4214-79-3 5-chloro-2-pyridinol 
• 4214-79-3 5-chloro-1,2-dihydropyridin-2-one 

Downstream Products

• 98027-36-2 3-amino-5-chloro-2-hydroxypyridine 
• 21427-62-3 2,5-dichloro-3-nitropyridine 
• 75806-86-9 2-bromo-5-chloro-3-nitropyridine 
• 22353-46-4 5-chloro-2-hydrazino-3-nitropyridine 
• 1443995-75-2 C₂₁H₂₅ClN₄O₄ 
• 1443995-76-3 C₂₆H₃₄ClN₅O₅ 
• 1407542-46-4 C₁₆H₁₇ClN₄O₂ 
• 1408054-69-2 C₂₁H₂₆ClN₅O₃ 
• 1441762-33-9 5-chloro-1-(4-methoxy-benzyl)-3-nitro-1H-pyridin-2-one 
• 1441762-26-0 3-amino-5-chloro-1-(4-methoxy-benzyl)-1H-pyridin-2-one 
• 1620583-26-7 ethyl 2-bromo-5-((5-chloro-1-methyl-2-oxo-1,2-dihydropyridin-3-ylamino)(4-chloro-3-fluorophenyl)methyl)-1-isopropyl-1H-imidazole-4-carboxylate 
• 1441769-24-9 3-amino-5-chloro-1-methyl-1H-pyridin-2-one 
• 1448870-68-5 2-bromo-5-[(5-chloro-1-methyl-2-oxo-1,2-dihydro-pyridin-3-ylamino)-(4-cyano-phenyl)-methyl]-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester 
• 1355342-91-4 N-[2-[[1-[2-(4-bromophenoxy)ethyl]-3-azetidinyl]oxy]-5,6-dichloro-3-pyridinyl]-2-chloro-4-pyridinecarboxamide 

Relevant articles and documents

Synthesis and evaluation of 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives as glycogen synthase kinase-3 (GSK-3) inhibitors

New potent glycogen synthase kinase-3 (GSK-3) inhibitors, 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives, were designed by modeling, synthesized and evaluated in vitro. Compound 17c showed good potency in enzyme and cell-based assays (IC50 = 111 nM, EC50 = 1.78 μM). Moreover, it has demonstrated desirable water solubility, PK profile, and moderate brain penetration.

Process for the preparation of (3-fluoropyridin-2-yloxy)phenoxypropionic acids

(3-Fluoropyridin-2-yloxy)phenoxypropionic acids of formula I STR1 wherein X is hydrogen, fluoro, chloro, bromo or trifluoromethyl and Y is hydrogen, sodium or potassium, are prepared by reacting a compound of formula II STR2 wherein X and Y are as defined for formula I, in an anhydrous mixture of hydrogen fluoride, dimethylsulfoxide and a diazotising agent under normal pressure, and converting the diazonium fluoride so produced by thermal decomposition into the (3-fluoropyridin-2-yloxy)phenoxypropionic acid of formula I.