214273-41-3

Upstream product

• 214273-39-9 2,2-Dimethyl-propionic acid (1S,4S,5S)-1-((R)-2-benzyloxy-1-methyl-ethyl)-5-hydroxy-4-methyl-7-trimethylsilanyl-hept-6-ynyl ester 
• 214273-36-6 2,2-Dimethyl-propionic acid (1S,4S)-1-((R)-2-benzyloxy-1-methyl-ethyl)-5-(tert-butyl-diphenyl-silanyloxy)-4-methyl-pentyl ester 
• 214273-38-8 2,2-Dimethyl-propionic acid (1S,4S)-1-((R)-2-benzyloxy-1-methyl-ethyl)-4-methyl-5-oxo-7-trimethylsilanyl-hept-6-ynyl ester 
• 214273-40-2 (3R,4S,7S,8R)-9-Benzyloxy-7-(2,2-dimethyl-propionyloxy)-3-hydroxy-4,8-dimethyl-nonanoic acid 
• 214273-37-7 2,2-Dimethyl-propionic acid (1S,4S)-1-((R)-2-benzyloxy-1-methyl-ethyl)-4-methyl-5-oxo-pentyl ester 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 81927-55-1 O-benzyl 2,2,2-trichloroacetimidate 

Relevant academic research and scientific papers

Stereoselective reduction of α'-branched α,β-ynones. Application to the synthesis of the octalactin A ring

A flexible, efficient route to chiral 3-hydroxy-4-methyl- and 3-hydroxy- 4-methoxyalkanoic acids, with high control of the C(3) configuration, has been disclosed, which is based on the borane-mediated reduction of 1- trimethylsilyl-1-alkyn-3-ones (6) in the presence of oxazaborolidine 7 followed by hydroboration of the resulting propargylic alcohols 4 and 5. This strategy has been applied to the synthesis of the Octalactin A ring.