214277-56-2Relevant academic research and scientific papers
1,1-Disilyl alcohols as d1 synthons: Harnessing the 1,2-Brook rearrangement
Fleming, Ian,Lawrence, Annabel J.,Richardson, Robert D.,Surry, David S.,West, Mark C.
, p. 3349 - 3365 (2007/10/03)
1,1-Disilyl alcohols like 6 give the silyl ethers like 9 on treatment with base and alkyl halides, in a reaction which may be formulated as the alkylation of the Brook-rearranged carbanion 8. The products can be oxidised to give ketones like 10, showing that this Brook-rearranging system supplies a controlled d1 synthon of the acyl anion class. The alcohols can be prepared from the acid chloride 12 and dimethyl(phenyl)silyllithium, but the intermediate anion 21 need not be worked up; it can be used directly in the alkylation step.
Allylation reactions of acylsilanes as synthetic equivalents of aldehydes. Application of a stereocontrolled synthesis of (1S,2S,5S)-(10S)- and-(10R)-allyl myrtanol
Bonini, Bianca Flavia,Comes-Franchini, Mauro,Fochi, Mariafrancesca,Mazzanti, Germana,Nanni, Cristiano,Ricci, Alfredo
, p. 6737 - 6740 (2007/10/03)
The allylation of acylsilanes with tetraallyltin in the presence of catalytic amounts of Sc(OTf)3 proceeded smoothly to afford the silylated homoallylic alcohols in good yields. Subsequent protiodesilylation gave the formal adducts of the corre
