214279-01-3

Upstream product

• 38233-96-4 ethyl 2-hydroxyacetate sodium salt 
• 203925-87-5 2-methylthio-4-chloro-5-nitro-6-(2-benzyloxy-5-cyanophenoxy)pyrimidine 
• 1979-96-0 4,6-dichloro-2-(methylthio)-5-nitropyrimidine 
• 194985-94-9 3-hydroxy-4-(benzyloxy)benzonitrile 

Downstream Products

• 214279-03-5 [6-(2-Benzyloxy-5-cyano-phenoxy)-2-methanesulfonyl-5-nitro-pyrimidin-4-yloxy]-acetic acid ethyl ester 
• 214279-08-0 3-[4-(2-Benzyloxy-5-cyano-phenoxy)-6-oxo-6,7-dihydro-5H-pyrimido[4,5-b][1,4]oxazin-2-yloxy]-N,N-dimethyl-benzamide 
• 214279-06-8 2-(3-dimethyl-aminocarbonylphenoxy)-4-(ethoxycarbonyl)methoxy-5-nitro-6-(2-benzyloxy-5-cyano-phenoxy)pyrimidine 

Relevant academic research and scientific papers

Design, synthesis, and biological activity of novel purine and bicyclic pyrimidine factor Xa inhibitors

The synthesis of amidinoaryloxy 9-benzyl-8-methyl-9H-purine, 7,8- dihydropteridine-6(5H)-one and 5,7-dihydropyrimido[4,5-b][1,4]oxazine-6-one inhibitors of Factor Xa is described. These compounds show nanomolar potency against FXa and maintain high selectivity over thrombin and trypsin.

BICYCLIC PYRIMIDINE DERIVATIVES AND THEIR USE AS ANTI-COAGULANTS

This invention is directed to bicyclic pyrimidine derivatives which are useful as anti-coagulants. This invention is also directed to pharmaceutical compositions containing the compounds of the invention, and methods of using the compounds to treat diseas