214279-07-9

Upstream product

• 214279-02-4 [6-(2-Benzyloxy-5-cyano-phenoxy)-2-methanesulfonyl-5-nitro-pyrimidin-4-ylamino]-acetic acid ethyl ester 
• 214279-00-2 2-methylthio-4-(ethoxycarbonylmethyl)amino-5-nitro-6-(2-benzyloxy-5-cyanophenoxy)pyrimidine 
• 203925-87-5 2-methylthio-4-chloro-5-nitro-6-(2-benzyloxy-5-cyanophenoxy)pyrimidine 
• 194985-94-9 3-hydroxy-4-(benzyloxy)benzonitrile 
• 15789-03-4 3-hydroxy-N,N-dimethylbenzamide 
• 214279-04-6 2-(3-dimethylaminocarbonylphenoxy)-4-(ethoxycarbonylmethyl)amino-5-nitro-6-(2-benzyloxy-5-cyanophenoxy)pyrimidine 

Relevant academic research and scientific papers

Design, synthesis, and biological activity of novel purine and bicyclic pyrimidine factor Xa inhibitors

The synthesis of amidinoaryloxy 9-benzyl-8-methyl-9H-purine, 7,8- dihydropteridine-6(5H)-one and 5,7-dihydropyrimido[4,5-b][1,4]oxazine-6-one inhibitors of Factor Xa is described. These compounds show nanomolar potency against FXa and maintain high selectivity over thrombin and trypsin.