214286-31-4Relevant academic research and scientific papers
Structure-based design of a parallel synthetic array directed toward the discovery of irreversible inhibitors of human rhinovirus 3C protease
Johnson, Theodore O.,Hua, Ye,Luu, Hiep T.,Brown, Edward L.,Chan, Fora,Chu, Shao Song,Dragovich, Peter S.,Eastman, Brian W.,Ferre, Rose Ann,Fuhrman, Shella A.,Hendrickson, Thomas F.,Maldonado, Fausto C.,Matthews, David A.,Meador III, James W.,Patick, Amy K.,Reich, Siegfried H.,Skalitzky, Donald J.,Worland, Stephen T.,Yang, Michelle,Zalman, Leora S.
, p. 2016 - 2023 (2002)
Utilizing the tools of parallel synthesis and structure-based design, a new class of Michael acceptor-containing, irreversible inhibitors of human rhinovirus 3C protease (HRV 3CP) was discovered. These inhibitors are shown to inhibit HRV-14 3CP with rates
Synthesis and antiinflammatory activities of 3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-ones
Ikuta,Shirota,Kobayashi,Yamagishi,Yamada,Yamatsu,Katayama
, p. 1995 - 1998 (2007/10/02)
A series of 3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-ones was synthesized and evaluated as candidate antiinflammatory/analgesic agents as well as dual inhibitors of prostaglandin and leukotriene synthesis. Some compounds that showed dual inh
