214287-66-8Relevant articles and documents
Structural and Rate Studies of the 1,2-Additions of Lithium Phenylacetylide to Lithiated Quinazolinones: Influence of Mixed Aggregates on the Reaction Mechanism
Briggs, Timothy F.,Winemiller, Mark D.,Collum, David B.,Parsons Jr., Rodney L.,Davulcu, Akin H.,Harris, Gregory D.,Fortunak, Joseph M.,Confalone, Pat N.
, p. 5427 - 5435 (2004)
The 1,2-addition of lithium phenylacetylide (PhCCLi) to quinazolinones was investigated using a combination of structural and rate studies. 6Li, 13C, and 19F NMR spectroscopies show that deprotonation of quinazolinones and
4,4-disubstituted-3,4-dihydro-2(1H)-quinazolinones useful as HIV reverse transcriptase inhibitors
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, (2008/06/13)
The present invention relates to 4,4-disubstituted-3,4-dihydro-2(1H)-quinazolinones of formula I: or steroisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent, wherein: R1 is C1-3 alkyl substituted with 1-7 halogen; R2 is optionally substituted C1-5 alkyl, optionally substituted C2-5 alkenyl, or optionally substituted C2-5 alkynyl; R3, at each occurrence, is independently selected from C1-4 alkyl, OH, C1-4 alkoxy, F, Cl, Br, I, NR5R5a, NO2, CN, C(O)R6, NHC(O)R7, and NHC(O)NR5R5a; R5 and R5a are independently selected from H and C1-3 alkyl; R6 is selected from H, OH, C1-4 alkyl, C1-4 alkoxy, and NR5R5a; R7 is selected from C1-3 alkyl and C1-3 alkoxy; R8 is selected from H, C3-5 cycloalkyl, and C1-3 alkyl; and, n is selected from 0, 1, 2, 3, and 4.