21429-32-3

Basic information

• Product Name: Benzaldehyde, 4-chloro-, (3-methyl-2(3H)-benzothiazolylidene)hydrazone
• CAS NO: 21429-32-3
• Molecular Formula: C15H12ClN3S
• Molecular Weight: 301.799
• Mol File: 21429-32-3.mol

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 4-chloro-, (3-methyl-2(3H)-benzothiazolylidene)hydrazone(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 4-chloro-, (3-methyl-2(3H)-benzothiazolylidene)hydrazone(21429-32-3)
• EPA Substance Registry System: Benzaldehyde, 4-chloro-, (3-methyl-2(3H)-benzothiazolylidene)hydrazone(21429-32-3)

Safety Data

• Hazardous Substances Data: 21429-32-3(Hazardous Substances Data)

Upstream product

• 1128-67-2 3-methyl-2-benzothiazolinone hydrazone 
• 104-88-1 4-chlorobenzaldehyde 
• 20064-98-6 2-methylthio-3-methylbenzothiazolium iodide 
• 615-22-5 2-methylmercaptobenzothiazole 
• 149-30-4 2-Mercaptobenzothiazole 

Relevant articles and documents

Design, synthesis and biological evaluation of novel unsymmetrical azines as quorum sensing inhibitors

Targeting quorum sensing signals using quorum sensing inhibitors has opened new avenues for the application of known antibiotics. In this context, twenty five unsymmetrical azines were synthesised and evaluated as quorum sensing inhibitors. An efficient one-pot procedure was adopted that directly links 3-methyl-2-(methylthio)benzo[d]thiazol-3-ium salt, hydrazine hydrate and substituted aldehyde to give the designed compounds. The synthesized compounds were preliminarily tested for their potential to inhibit CviR receptor based QS signals in Chromobacterium violaceum. The bioassay screening results suggested that two compounds exhibited potent QS inhibition activity against CviR receptor, showing violacein inhibition (>50%) at 200 μM. Further, the putative positive hits were checked for their potential to inhibit LasR receptor-based QS using the PlasB-gfp(ASV) biomonitor strain of Pseudomonas aeruginosa. These compounds were found to inhibit the QS-mediated GFP signals in a dose dependant manner. Two active compounds also exhibited biofilm clearance at 50 μM concentration. Docking studies were performed to examine their potential to bind to the LasR protein of Pseudomonas aeruginosa.

Synthesis and antitumor evaluation of new heterocycles derived from 3-Methyl-2-benzothiazolinone Hydrazone

3-Methyl-2-benzothiazolinone hydrazone condensed with some selected aldehydes to give the corresponding Schiff bases. Cyclizing the obtained Schiff base derivatives with thioglycolic acid afforded the respective thiazolylideneaminothiazolidenones. Condens

Synthesis and isomerism of azines based on 3-methyl-2-benzothiazolinone hydrazone

It was found by ESR spectroscopy that asymmetric azines obtained from 3-methyl-2-benzothiazolinone hydrazone can exist in solutions in the form of a mixture of syn and anti isomers, depending on the structure of the carbonyl compound introduced into the c