214325-99-2Relevant articles and documents
Synthesis and preliminary biological evaluation of new α-amino amide anticonvulsants incorporating a dextromethorphan moiety
Pevarello, Paolo,Traquandi, Gabriella,Bonsignori, Alberto,McArthur, Robert A.,Maj, Roberto,Caccia, Carla,Salvati, Patricia,Varasi, Mario
, p. 1783 - 1788 (2007/10/03)
Dextromethorphan 1 is an effective neuroprotectant in animal models of epilepsy and ischemia but showed side-effects during clinical trials limiting its potential use in a clinical setting. Here we describe the enantioselective and enantiospecific syntheses and the initial in vitro and in vivo biological evaluation of new hybrid structures between 1 and a previously disclosed α-amino amide anticonvulsant (3).