214331-53-0 Usage
Uses
Used in Oncology:
Hydroxyurea-15N is used as an anti-neoplastic agent for its ability to inhibit ribonucleoside reductase and DNA replication, making it a valuable tool in the treatment of various types of cancer. Its effectiveness in disrupting cancer cell proliferation contributes to its widespread use in oncology.
Used in Sickle Cell Anemia Treatment:
Hydroxyurea-15N is used as a potential therapy for sickle cell anemia due to its role in the nitrosylation of sickle cell hemoglobin. This process is facilitated by the horseradish peroxidase-catalyzed formation of nitric oxide from hydroxyurea in the presence of hydrogen peroxide, which can help alleviate the symptoms and complications associated with sickle cell anemia.
Used in Pharmaceutical Research:
As a labeled compound, Hydroxyurea-15N can be utilized in pharmaceutical research to study the mechanisms of action, metabolic pathways, and potential drug interactions involving hydroxyurea. This can lead to the development of new therapeutic strategies and improved understanding of the compound's effects on biological systems.
Check Digit Verification of cas no
The CAS Registry Mumber 214331-53-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,4,3,3 and 1 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 214331-53:
(8*2)+(7*1)+(6*4)+(5*3)+(4*3)+(3*1)+(2*5)+(1*3)=90
90 % 10 = 0
So 214331-53-0 is a valid CAS Registry Number.
InChI:InChI=1/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)/i3+1
214331-53-0Relevant academic research and scientific papers
Yasaki, Genichiro,Xu, Yueping,King, S. Bruce
, p. 2041 - 2047 (2000)
Treatment of trimethylsilyl isocyanate with 15N-hydroxylamine hydrochloride produces 15N-hydroxyurea, a valuable pharmacological tool, in an efficient, one-pot procedure in 74% yield. Recrystallization of the crude product yields analytically pure material in 47% overall yield.
