214341-15-8Relevant articles and documents
Discovery of MC-02,331, a new cephalosporin exhibiting potent activity against methicillin-resistant staphylococcus aureus
Hecker, Scott J.,Cho, In-Seop,Glinka, Tomasz W.,Zhang, Zhijia J.,Price, Mary E.,Lee, Ving J.,Christensen, Burton G.,Boggs, Amy,Chamberland, Suzanne,Malouin, Francois,Parr, Thomas R.,Annamalai, Thamil,Blais, Johanne,Bond, Emmett L.,Case, Laura,Chan, Christine,Crase, Jac,Frith, Ria,Griffith, David,Harford, Laurie,Liu, Nancy,Ludwikow, Maria,Mathias, Kristina,Rea, David,Williams, Robert
, p. 722 - 734 (2007/10/03)
A systematic approach toward building activity against methicillin-resistant staphylococci into the cephalosporin class of β-lactam antibiotics is described. Initial work focused on finding the optimal linkage between the cephem nucleus and a biphenyl pha