214344-21-5Relevant academic research and scientific papers
(S)-N-triphenylmethylpyroglutamyl fluoride
Nastopoulos, Vassilios,Karigiannis, George,Mamos, Petros,Papaioannou, Dionissios,Kavounis, Constantin
, p. 1718 - 1720 (1998)
The title compound, C24H20FNO2, is the product of the reaction of (S)-N-triphenylmethylpyroglutamic acid with cyanuric fluoride in the presence of pyridine. The crystal structure determination shows the presence of two cry
Preparation and properties of enantiomerically pure Nα-tritylamino acid fluorides
Karygiannis, Georgios,Athanassopoulos, Costas,Mamos, Petros,Karamanos, Nikolaos,Papaioannou, Dionissios,Francis, George W.
, p. 1144 - 1150 (2007/10/03)
Cyanuric fluoride-mediated fluorination of chiral Nα-tritylamino acids leads to the corresponding acyl fluorides which are powerful acylating agents for peptide synthesis. The acyl fluorides react with NaBH4, the stabilized phosphorane Ph3P=C(Me)CO2Me and Ruppert's reagent providing access to enantiomerically pure tritylamino alcohols, alkenes and trifluoromethyl ketones, respectively. Acta Chemica Scandinavica 1998.
