214358-33-5 Usage
Uses
Used in Pharmaceutical Industry:
1400 W DIHYDROCHLORIDE, 96 is used as a selective inducible nitric oxide synthase (iNOS) inhibitor for its ability to modulate various signaling pathways and exert inhibitory effects on tumor growth and progression.
Used in Medical Research:
1400 W DIHYDROCHLORIDE, 96 is used as a long-acting human iNOS inhibitor with an IC50 value of 2.0uM for studying its efficacy on various medical conditions, such as intestinal ischemia/reperfusion injury, PM10-induced endothelial dysfunction, renal ischemia/reperfusion injury, and counteracting spatial memory deficits after hypobaric hypoxia reoxygenation.
Used in Drug Delivery Systems:
1400 W DIHYDROCHLORIDE, 96 is used in the development of novel drug delivery systems to enhance its applications and efficacy against various medical conditions by improving its delivery, bioavailability, and therapeutic outcomes.
Biochem/physiol Actions
Cell permeable: yes
References
References/Citations
1) Garvey?et al. (1997),?1400W is a slow, tight-binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo; J. Biol. Chem.,?272?4959
2) Thomsen?et al. (1997),?Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: Studies with 1400W, a novel inhibitor; Cancer Res.,?57?3300
3) Pigott?et al. (2013),?On the selectivity of neuronal NOS inhibitors; Br. J. Pharmacol.,?168?1255
Check Digit Verification of cas no
The CAS Registry Mumber 214358-33-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,4,3,5 and 8 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 214358-33:
(8*2)+(7*1)+(6*4)+(5*3)+(4*5)+(3*8)+(2*3)+(1*3)=115
115 % 10 = 5
So 214358-33-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H15N3/c1-8(12)13-7-10-4-2-3-9(5-10)6-11/h2-5H,6-7,11H2,1H3,(H2,12,13)/p+2
