2144-87-8

Basic information

• Product Name: (3aR,7aS)-rel-2,3,3a,4,7,7a-Hexahydro-1H-isoindole
• Synonyms: (3aR,7aS)-rel-2,3,3a,4,7,7a-Hexahydro-1H-isoindole;cis-2,3,3a,4,7,7a-Hexahydro-1H-isoindole
• CAS NO: 2144-87-8
• Molecular Formula: C₈H₁₃N
• Molecular Weight: 123.19552
• Mol File: 2144-87-8.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 183℃
• Flash Point: 61℃
• Appearance: /
• Density: 0.947
• PKA: 11.15±0.20(Predicted)
• CAS DataBase Reference: (3aR,7aS)-rel-2,3,3a,4,7,7a-Hexahydro-1H-isoindole(CAS DataBase Reference)
• NIST Chemistry Reference: (3aR,7aS)-rel-2,3,3a,4,7,7a-Hexahydro-1H-isoindole(2144-87-8)
• EPA Substance Registry System: (3aR,7aS)-rel-2,3,3a,4,7,7a-Hexahydro-1H-isoindole(2144-87-8)

Safety Data

• Hazardous Substances Data: 2144-87-8(Hazardous Substances Data)

Usage

General Description

(3aR,7aS)-rel-2,3,3a,4,7,7a-Hexahydro-1H-isoindole is a chemical compound with a molecular formula of C9H15N. This substance is a type of isoindole, which is a heterocyclic compound containing a six-membered ring with two nitrogen atoms. (3aR,7aS)-rel-2,3,3a,4,7,7a-Hexahydro-1H-isoindole has a bicyclic structure and is commonly used as a building block in the synthesis of various organic compounds. It is also known for its potential biological activity and is being studied for its potential pharmaceutical applications. Additionally, this compound may have applications in materials science and chemical engineering as a precursor for the synthesis of new materials with specific properties.

Upstream product

• 1469-48-3 cis-1,2,3,6-Tetrahydrophthalimide 

Downstream Products

• 10533-25-2 ((3ar,7ac)-1,3,3a,4,7,7a-hexahydro-isoindol-2-yl)-acetonitrile 
• 245036-93-5 N-phenyloxycarbonyl-meso-8-azabicyclo[4.3.0]non-3-ene 
• 474925-37-6 (3aR,7aS)-tert-butyl 3a,4,7,7a-tetrahydro-1H-isoindole-2(3H)-carboxylate 
• 318502-89-5 N-BOC-octahydro-1H-isoindol-5-ol 
• 150492-65-2 cis-2-(3,4-dichlorophenethyl)-3a,4,7,7a-tetrahydroisoindoline 
• 1470-99-1 cis-hexahydroisoindoline 

Relevant articles and documents

Purine derivative and preparation method and application thereof

The invention discloses a purine derivative and a preparation method and application thereof, belongs to the technical field of medicines, and designs and synthesizes a series of purine derivatives and optical isomers, pharmaceutically acceptable salts, solvates or prodrugs of the purine derivatives. Experiments show that the compound has outstanding anti-cell proliferation activity and DOT1L enzyme inhibition effect, shows good tumor growth inhibition activity in a tumor transplantation tumor model, and has a good application prospect.

Octahydrocyclopenta[c]pyrrole Allosteric Inhibitors of SHP2

The present invention relates to compounds capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds, and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

An Efficient and Scalable Synthesis of tert-Butyl (3aR,6aS)-5-Oxohexahydrocyclo penta[c]pyrrole-2(1H)-carboxylate: A Pharmacologically Important Intermediate

Hexahydrocyclopentapyrrolone derivatives constitute an important class of bicycles, and it represents an essential pharmacophore for diversified pharmacological activities. A highly efficient process for the synthesis of tert-butyl(3aR,6aS)-5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate 1 has been developed. The improved process involves transformation of isoindole 4 to diacid 5, using an inexpensive KMnO4 mediated oxidative cleavage as a key step. The developed process was cost-effective, high yielding, kilogram scalable, and commercially viable for synthesis of 1.