214402-99-0Relevant articles and documents
Synthesis and NMR analysis of 13C-labeled oligosaccharides corresponding to the major glycolipid from Mycobacterium leprae
Wu, Ximao,Marino-Albernas, Jose-R,Auzanneau, France-Isabelle,Verez-Bencomo, Vicente,Pinto, B. Mario
, p. 493 - 503 (2007/10/03)
An improved synthesis of propyl 4-O-(3,6-di-O-methyl-β-D- glucopyranosyl)-2,3-di-O-methyl-α-L-rhamnopyranoside, a disaccharide corresponding to the phenolic glycolipid of Mycobacterium leprae using a trichloroacetimidate as a glycosyl donor is described. The synthetic strategy is also applied to the preparation of three corresponding disaccharide analogues containing 13C-labeled methyl groups. The preparation of the trisaccharide, propyl 2-O-[4-O-(3,6-di-O-methyl-β-D-glucopyranosyl)-2,3-di- O-methyl-α-L-rhamnopyranosyl]-3-O-methyl-α-L-rhamnopyranoside is also reported. The di- and tri-saccharides were characterized by 1H and 13C NMR spectroscopy.