214460-99-8Relevant academic research and scientific papers
Methods for binding agents to b-amyloid plaques
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Page/Page column 7, (2010/11/26)
A method for labeling structures, such as β-amyloid plaques and neurofibrillary tangles, in vivo or in vitro, is provided and comprises contacting brain tissue with one or more compounds, preferably radiolabeled for detection by positron emission tomography (PET).
Methods for labeling β-amyloid plaques and neurofibrillary tangles
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, (2008/06/13)
A method for labeling β-amyloid plaques and neurofibrillary tangles in vivo and in vitro, comprises contacting a compound of formula (I): with mammalian tissue. In formula (I), R1is selected from the group consisting of —C(O)-alkyl, —C(O)-alkylenyl-R4, —C(O)O-alkyl, —C(O)O-alkylenyl-R4, —C═C(CN)2-alkyl, —C═C(CN)2-alkylenyl-R4, R4is a radical selected from the group consisting of alkyl, substituted alkyl, aryl and substituted aryl; R5, is a radical selected from the group consisting of —NH2, —OH, —SH, —NH-alkyl, —NHR4, —NH-alkylenyl-R4, —O-alkyl, —O-alkylenyl-R4, —S-alkyl, and —S-alkylenyl-R4; R6is a radical selected from the group consisting of —CN, —COOH, —C(O)O-alkyl, —C(O)O-alkylenyl-R4, —C(O)-alkyl, —C(O)-alkylenyl-R4, —C(O)-halogen, —C(O)NH , —C(O)NH-alkyl, —C(O)NH-alkylenyl-R4; R7is a radical selected from the group consisting of O, NH, and S; and R8is N, O or S. R2and R3are each independently selected from the group consisting of alkyl and alkylenyl-R10, wherein R10is selected from the group consisting of —OH, —OTs, halogen, spiperone, spiperone ketal and spiperone-3-yl. Alternatively, R2and R3together form a heterocyclic ring, optionally substituted with at least one radical selected from the group consisting of alkyl, alkoxy, OH, OTs, halogen, alkylenyl-R10, carbonyl, spiperone, spiperone ketal and spiperone-3-yl. In the compounds of formula (I), one or more of the hydrogen, halogen or carbon atoms can, optionally, be replaced with a radiolabel.
Novel fluorescent reactive dyes as intermediates for the preparation of UV and vis wavelength fluorescent probes
Petric, Andrej,Spes, Tatjana,Barrio, Jorge R.
, p. 777 - 786 (2007/10/03)
To prepare reactive dyes matching the optical properties of 2-(1,1-dicyano-propenyl-2)-6-dimethylaminonaphthalene (DDNP), 2-ethylaminoethanol or 4-piperidinemethanol were used in a Bucherer reaction with 1-(6-hydroxy-2-naphthyl)-1-ethanone. The two amines were chosen to mimic the dimethylamino group's steric and electronic (inductive) effects and to provide a reactive site for ligand attachment. The intermediate hydroxy derivatives were transformed into fluorescent reactive p-toluenesulfonic acid esters which in turn were conjugated to the test ligand spiperone. Knoevenagel condensation with malononitrile afforded Vis wavelength fluorescent probes.
