214461-06-0

Upstream product

• 214460-98-7 1-{6-[(4-hydroxymethyl)-piperidino]-2-naphthyl}-1-ethanone 
• 10441-41-5 1-(6-hydroxy-2-naphthyl)ethan-1-one 
• 3900-45-6 6-methoxy-2-acetylnaphthalene 
• 54080-21-6 8-<3-<2-(4-fluorophenyl)-1,3-dioxolan-2-yl>propyl>-1-phenyl-1,3,8-triazaspiro<4.5>decan-4-one 
• 214461-04-8 1-(6-acetyl-2-naphthyl)-4-<(4-methylphenyl)sulfonyloxy> methylpiperidine 

Relevant academic research and scientific papers

Methods for binding agents to b-amyloid plaques

A method for labeling structures, such as β-amyloid plaques and neurofibrillary tangles, in vivo or in vitro, is provided and comprises contacting brain tissue with one or more compounds, preferably radiolabeled for detection by positron emission tomography (PET).

Novel fluorescent reactive dyes as intermediates for the preparation of UV and vis wavelength fluorescent probes

To prepare reactive dyes matching the optical properties of 2-(1,1-dicyano-propenyl-2)-6-dimethylaminonaphthalene (DDNP), 2-ethylaminoethanol or 4-piperidinemethanol were used in a Bucherer reaction with 1-(6-hydroxy-2-naphthyl)-1-ethanone. The two amines were chosen to mimic the dimethylamino group's steric and electronic (inductive) effects and to provide a reactive site for ligand attachment. The intermediate hydroxy derivatives were transformed into fluorescent reactive p-toluenesulfonic acid esters which in turn were conjugated to the test ligand spiperone. Knoevenagel condensation with malononitrile afforded Vis wavelength fluorescent probes.