214491-07-3 Usage
Description
Kotalanol, a potent natural α-glucosidase inhibitor, is an antidiabetic agent derived from the roots and stems of Salacia reticulata Wight. It exhibits more potent inhibitory activity against sucrase compared to Salacinol (S085200) and Acarbose (A123500), making it a promising candidate for the development of treatments for diabetes and related metabolic disorders.
Uses
Used in Pharmaceutical Industry:
Kotalanol is used as an antidiabetic agent for its potent inhibitory activity against sucrase, which helps in managing blood sugar levels and improving the overall metabolic health of individuals with diabetes.
Used in Drug Development:
Kotalanol is used as a key component in the development of new drugs targeting diabetes and related metabolic disorders due to its effectiveness in inhibiting α-glucosidase, a crucial enzyme involved in carbohydrate metabolism.
Used in Research and Development:
Kotalanol serves as an important compound in research and development for understanding the mechanisms of diabetes and the potential of natural products in the treatment and management of the disease. Its potent inhibitory activity against sucrase makes it a valuable tool for studying the enzyme's role in carbohydrate metabolism and the development of novel therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 214491-07-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,4,4,9 and 1 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 214491-07:
(8*2)+(7*1)+(6*4)+(5*4)+(4*9)+(3*1)+(2*0)+(1*7)=113
113 % 10 = 3
So 214491-07-3 is a valid CAS Registry Number.
214491-07-3Relevant articles and documents
SALACINOL AND PONKORANOL HOMOLOGUES, DERIVATIVES THEREOF, AND METHODS OF SYNTHESIZING SAME
-
, (2011/06/25)
Salacinol and ponkoranol homologues, derivatives thereof and methods of synthesizing and using said homologies and derivatives. The derivatives include stereoisomers, de-O-sulfonated compounds and congeners of the naturally occurring homologues. Some of the derivatives exhibit enhanced glucosidase inhibitory bioactivity in comparison to the naturally occurring compounds which have been isolated from salacia reticulata.
METHODS FOR SYNTHESIZING KOTALANOL AND STEREOISOMERS AND ANALOGUES THEREOF, AND NOVEL COMPOUNDS PRODUCED THEREBY
-
Page/Page column 54-55, (2009/10/22)
Compounds having the general formula (I): wherein X is S, Se or NH, and stereoisomers thereof, and de-O-sulfonated analogues of all of the foregoing, but excluding naturally occurring kotalanol and de-O-sulfonated kotalanol, and methods for synthesizing same. The compounds are useful as glycosidase inhibitors, and may be used in the treatment of diabetes. The synthetic compounds may also be used as standards in the calibration or grading of natural or herbal remedies produced from natural sources of glycosidase inhibitors such as kotalanol.