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1-(2-deoxy-alpha-D-erythro-pentofuranosyl)-5-fluoropyrimidin-2(1H)-one, also known as 5-fluorouracil (5-FU), is a fluorinated pyrimidine analog that plays a significant role in cancer chemotherapy. It is a nucleoside analog, meaning it resembles the natural nucleosides found in DNA and RNA. 5-FU is primarily used to treat various types of cancer, including colorectal, breast, stomach, and head and neck cancers. The compound works by inhibiting the enzyme thymidylate synthase, which is essential for DNA synthesis, thereby disrupting the cell cycle and ultimately leading to cell death. Due to its mechanism of action, 5-FU is particularly effective in treating rapidly dividing cancer cells. However, it can also cause side effects, such as diarrhea, nausea, and bone marrow suppression, as it affects both cancerous and healthy cells.

2145-71-3

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2145-71-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2145-71-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,1,4 and 5 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 2145-71:
(6*2)+(5*1)+(4*4)+(3*5)+(2*7)+(1*1)=63
63 % 10 = 3
So 2145-71-3 is a valid CAS Registry Number.

2145-71-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(β-D-erythro-2-deoxy-pentofuranosyl)-5-fluoro-1H-pyrimidin-2-one

1.2 Other means of identification

Product number -
Other names 5-Fluoro-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2145-71-3 SDS

2145-71-3Upstream product

2145-71-3Downstream Products

2145-71-3Relevant academic research and scientific papers

Differential Inhibition of APOBEC3 DNA-Mutator Isozymes by Fluoro- and Non-Fluoro-Substituted 2′-Deoxyzebularine Embedded in Single-Stranded DNA

Kvach, Maksim V.,Barzak, Fareeda M.,Harjes, Stefan,Schares, Henry A. M.,Kurup, Harikrishnan M.,Jones, Katherine F.,Sutton, Lorraine,Donahue, John,D'Aquila, Richard T.,Jameson, Geoffrey B.,Harki, Daniel A.,Krause, Kurt L.,Harjes, Elena,Filichev, Vyacheslav V.

, p. 1028 - 1035 (2020/01/02)

The APOBEC3 (APOBEC3A-H) enzyme family is part of the human innate immune system that restricts pathogens by scrambling pathogenic single-stranded (ss) DNA by deamination of cytosines to produce uracil residues. However, APOBEC3-mediated mutagenesis of vi

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