21453-26-9Relevant academic research and scientific papers
The Catalytic Asymmetric Mukaiyama–Michael Reaction of Silyl Ketene Acetals with α,β-Unsaturated Methyl Esters
Gatzenmeier, Tim,Kaib, Philip S. J.,Lingnau, Julia B.,Goddard, Richard,List, Benjamin
supporting information, p. 2464 - 2468 (2018/02/06)
α,β-Unsaturated esters are readily available but challenging substrates to activate in asymmetric catalysis. We now describe an efficient, general, and highly enantioselective Mukaiyama–Michael reaction of silyl ketene acetals with α,β-unsaturated methyl esters that is catalyzed by a silylium imidodiphosphorimidate (IDPi) Lewis acid.
The Michael Reaction of O-Silylated Ketene Acetals with α,β-Unsaturated Esters Promoted by a Catalytic Amount of Aluminium Triflate
Minowa, Nobuto,Mukaiyama, Teruaki
, p. 1719 - 1722 (2007/10/02)
The Michael reaction of O-silylated ketene acetals with α,β-unsaturated ester in the presence of a catalytic amount of aluminium triflate proceeds smoothly under mild conditions to afford the corresponding glutarates in good yields.
