214533-24-1

Basic information

• Product Name: (2R,4S,5S,6R,7R,8S,10S,11S,12R,14S,17S,20R)-5,7-bis(tert-butyldimethylsilyloxy)-1,2-isopropylidenedioxy-14-(4-methoxybenzyloxy)-6,12-dimethyl-18-methylidene-11-toluenesulfonyloxymethyl-21-<2-(trimethylsilyl)ethoxymethoxy>-4,8; 17,20-diepoxyhenicosan-...
• Synonyms: (2R,4S,5S,6R,7R,8S,10S,11S,12R,14S,17S,20R)-5,7-bis(tert-butyldimethylsilyloxy)-1,2-isopropylidenedioxy-14-(4-methoxybenzyloxy)-6,12-dimethyl-18-methylidene-11-toluenesulfonyloxymethyl-21-<2-(trimethylsilyl)ethoxymethoxy>-4,8; 17,20-diepoxyhenicosan-...
• CAS NO: 214533-24-1
• Molecular Weight: 1179.83
• Mol File: 214533-24-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,4S,5S,6R,7R,8S,10S,11S,12R,14S,17S,20R)-5,7-bis(tert-butyldimethylsilyloxy)-1,2-isopropylidenedioxy-14-(4-methoxybenzyloxy)-6,12-dimethyl-18-methylidene-11-toluenesulfonyloxymethyl-21-<2-(trimethylsilyl)ethoxymethoxy>-4,8; 17,20-diepoxyhenicosan-...(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4S,5S,6R,7R,8S,10S,11S,12R,14S,17S,20R)-5,7-bis(tert-butyldimethylsilyloxy)-1,2-isopropylidenedioxy-14-(4-methoxybenzyloxy)-6,12-dimethyl-18-methylidene-11-toluenesulfonyloxymethyl-21-<2-(trimethylsilyl)ethoxymethoxy>-4,8; 17,20-diepoxyhenicosan-...(214533-24-1)
• EPA Substance Registry System: (2R,4S,5S,6R,7R,8S,10S,11S,12R,14S,17S,20R)-5,7-bis(tert-butyldimethylsilyloxy)-1,2-isopropylidenedioxy-14-(4-methoxybenzyloxy)-6,12-dimethyl-18-methylidene-11-toluenesulfonyloxymethyl-21-<2-(trimethylsilyl)ethoxymethoxy>-4,8; 17,20-diepoxyhenicosan-...(214533-24-1)

Safety Data

• Hazardous Substances Data: 214533-24-1(Hazardous Substances Data)

Upstream product

• 157158-47-9 (2S,5R)-2-<(3S,5R)-6-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-5-methylhexyl>-5-benzoyloxymethyl-3-(methylidene)tetrahydrofuran 
• 157158-46-8 (2S,3S,5R)-2-<(3S,5R)-6-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-5-methyhexyl>-5-(benzoyloxymethyl)tetrahydrofuran-3-ol 
• 214532-94-2 (2S,5R)-5-(benzoyloxymethyl)-2-<(3S,5R)-6-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-5-methyhexyl>tetrahydrofuran-3-one 
• 157158-43-5 (2R,3S,5R)-2-<(1S,3R,5R)-6-(tert-butyldiphenylsilyloxy)-1-iodo-3-(4-methoxybenzyloxy)-5-methylhexyl>-5-(hydroxymethyl)tetrahydrofuran-3-ol 
• 157158-45-7 (5E,2R,4S,8S,10R)-11-(tert-butyldiphenylsilyloxy)-1,2-isopropylidenedioxy-8-(4-methoxybenzyloxy)-10-methyl-5-undecen-4-ol 
• 157158-42-4 (5E,2R,4S,8S,10R)-11-(tert-butyldiphenylsilyloxy)-8-(4-methoxybenzyloxy)-10-methyl-5-undecene-1,2,4-triol 
• 157158-44-6 (5E,2R,8S,10R)-11-(tert-butyldiphenylsilyloxy)-1,2-isopropylidenedioxy-8-(4-methoxybenzyloxy)-10-methyl-5-undecen-4-one 
• 214533-02-5 (2S,3S,5R)-2-<(3S,5R)-6-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-5-methyhexyl>-5-(hydroxymethyl)tetrahydrofuran-3-ol 
• 214533-01-4 (2S,3S,5R)-2-<(1E,3R,5R)-6-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-5-methy-1-hexenyl>-5-(hydroxymethyl)tetrahydrofuran-3-ol 
• 214533-06-9 (3S,5S)-5-(4-Methoxy-benzyloxy)-3-methyl-7-[(2S,5R)-3-methylene-5-(2-trimethylsilanyl-ethoxymethoxymethyl)-tetrahydro-furan-2-yl]-heptanenitrile 
• 214533-08-1 (3R,5S)-5-(4-Methoxy-benzyloxy)-3-methyl-7-[(2S,5R)-3-methylene-5-(2-trimethylsilanyl-ethoxymethoxymethyl)-tetrahydro-furan-2-yl]-heptanal 
• 214532-95-3 (3R,5S)-7-<(2S,5R)-5-benzoyloxymethyl-3-(methylidene)tetrahydrofuryl>-5-(4-methoxybenzyloxy)-3-methylheptanenitrile 
• 214533-03-6 (2S,5R)-2-<(3S,5R)-6-hydroxy-3-(4-methoxybenzyloxy)-5-methylhexyl>-5-benzoyloxymethyl-3-(methylidene)tetrahydrofuran 
• 214532-93-1 (3R,5R)-6-(tert-butyldiphenylsilyloxy)-3-(4-methoxybenzyloxy)-5-methyl-1-hexenol 

Relevant articles and documents

Synthetic studies on halichondrin B, an antitumor polyether macrolide isolated from a marine sponge. 9. Synthesis of the C16 - C36 unit via stereoselective construction of the D and E rings

The C16 - C36 unit of halichondrin B was stereoselectively synthesized via the aldol condensation of two C16 - C26 esters with the previously synthesized C27 - C36 aldehyde followed by E ring construction. The C16 - C26 esters were prepared starting from (2S)-3-hydroxy-2-methylpropionic acid and L-tartaric acid via construction of the D ring by iodoetherification.